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Synthesis and Biological Evaluation of 2,5-Diaminobenzamide Derivatives as Anti-proliferating Agents

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Author(s)
Sang-Hyo LeeJong-Won ParkJi-Eun HongJong-Wook ParkJinho Lee
Keimyung Author(s)
Park, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
Archives of Pharmacal Research
Issued Date
2009
Volume
32
Issue
6
Abstract
The screening of the chemical library for the anti-proliferative activity of the chemical library provided 2,5-diaminobenzamide as the initial hit. The confirmation and the optimization of hit were performed by synthesis followed by the evaluation of growth inhibitory activity against human cancer cell lines. The most active growth inhibitor showed IC50 of 1.0 μM. The compound 7 increased not only sub-G1 population but also number of cells which are stained with Annexin V-FITC and 7-AAD, suggesting that compound 7 induced cell death is apoptosis.


Key words
Anti-cancer agent – 2,5-Diaminobenzamide – Growth inhibitory activity – Apoptosis
Keimyung Author(s)(Kor)
박종욱
Publisher
School of Medicine
Citation
Sang-Hyo Lee et al. (2009). Synthesis and Biological Evaluation of 2,5-Diaminobenzamide Derivatives as Anti-proliferating Agents. Archives of Pharmacal Research, 32(6), 803–812. doi: 10.1007/s12272-009-1600-8
Type
Article
ISSN
0253-6269
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs12272-009-1600-8
DOI
10.1007/s12272-009-1600-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35081
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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