계명대학교 의학도서관 Repository

Photodynamic therapy suppresses tumor growth in an in vivo model of human hemangioma

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Author(s)
Jaehoon ChoiWoo Jung KimSang Woo ParkLianji XuSang-Hyon KimHye Sook MinGeun-Yong KwonChung-Hyun ChoSukwha KimTae Hyun Choi
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Archives of Dermatological Research
Issued Date
2014
Volume
306
Issue
1
Abstract
The authors investigated the efficacy of photodynamic therapy against infantile hemangioma using a hemangioma animal model. Eighty-three hemangioma specimens from five children were implanted into nude mice. The gross and volume changes of the implants were evaluated for up to 13 weeks. The histological change of the implant was evaluated at 5 weeks after transplantation. Photodynamic therapy was performed between 6 and 10 weeks after transplantation. The photosensitizer uptake of the implant was evaluated at 24 h after photosensitizer administration. The implant response was evaluated at 0, 12, and 24 h after light delivery. The change in ATF3 levels, a transcription factor induced under severe hypoxic conditions, was investigated immediately after treatment. The implant volume increased slowly during the first 4 weeks and then involuted. At 5 weeks after transplantation, plump endothelial cells formed tightly packed sinusoidal channels, and the endothelial cells were positive for CD31 and GLUT1 expression. At 24 h after photosensitizer administration, confocal analysis showed that the photosensitizer was present within CD31-positive cells. The implant volume was significantly decreased in the treated implants compared with the untreated implants (p < 0.0001). At 24 h after light delivery, most cells had collapsed. ATF3 expression increased gradually and then reached a maximum level at 4 h after treatment. Photodynamic therapy was effective in the treatment of infantile hemangioma. Apoptosis, a major mechanism of hemangioma destruction in the early phase, might be caused by ischemic injury as well as direct effects of photodynamic therapy..
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine
Citation
Jaehoon Choi et al. (2014). Photodynamic therapy suppresses tumor growth in an in vivo model of human hemangioma. Archives of Dermatological Research, 306(1), 81–91. doi: 10.1007/s00403-013-1378-x
Type
Article
ISSN
0340-3696
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007/s00403-013-1378-x
DOI
10.1007/s00403-013-1378-x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35084
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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