Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft
- Affiliated Author(s)
- 김준형; 손대구; 한기환
- Alternative Author(s)
- Kim, Jun Hyung; Son, Dae Gu; Han, Ki Hwan
- Journal Title
- Archives of Plastic Surgery
- Issued Date
- Background For patients with neuropathy, vasculopathy, and impairment of wound
healing, treatment of a diabetic foot ulcer poses many challenges. A large number of dermal
analogues have been invented in an effort to overcome these challenges. Matriderm, a
dermal analogue, is made from bovine collagen and elastin. This study was conducted in
order to evaluate the effectiveness of Matriderm for treatment of diabetic foot ulcers, in
comparison with skin grafting.
Methods Sixty patients with diabetic foot ulcer were included in this prospective study. The
average age of the patients, who had type II diabetes mellitus, was 58 years old. The patients
were allocated to an experimental or control group with their consents. The patients were
selected with their consent for inclusion in an experimental group and a control group.
Patients in the experimental group received a Matriderm appliance and a split-thickness skin
graft, while those in the control group received only a split-thickness skin graft.
Results A shorter hospitalization period (7.52 weeks) was observed in the experimental group
than in the control group (9.22 weeks), and a shorter period of time (8.61 weeks) was required
for complete healing, compared with the control group (12.94 weeks), with statistical
significance (P<0.05). A higher elasticity ratio of the affected side to the non-affected side
was observed in the experimental group, compared with the control group (P<0.01).
Conclusions Matriderm enables effective healing and improves elasticity in treatment of
patients with diabetic foot ulcer.
Keywords Skin / Diabetes complications / Skin transplantation
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