Metabolic Syndrome Is Associated With Venous Thromboembolism in the Korean Population
- Affiliated Author(s)
- Alternative Author(s)
- Choi, Won Il
- Journal Title
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Issued Date
- Background—The metabolic syndrome (MS) is a known risk factor for arterial thromboembolism. Preliminary reports
have also suggested the association between MS and venous thromboembolism (VTE).
Methods and Results—In this case– control study, we investigated the association between MS and VTE in Korean
patients. Patients with objectively diagnosed VTE and healthy control subjects underwent clinical assessment for the
presence of MS according to the National Cholesterol Education Adult Treatment Panel III criteria modified with body
mass index (WHO Asian Pacific Perspective, 2000). The presence of known risk factors for VTE was ascertained.
Patients with VTE secondary to cancer were excluded. The prevalence of MS was compared between VTE group and
controls. Two hundred eight VTE patients and 300 controls were assessed. VTE was idiopathic in 91 patients and
secondary to a known risk factor in 117. The prevalence of MS was significantly higher in VTE patients (47.6%) than
in controls (37.7%) (OR: 1.50; 95% CI: 1.05 to 2.15, P 0.026). After adjusting for age, sex, and smoking status,
metabolic MS remained independently associated with VTE (OR: 1.56; 95% CI: 1.07 to 2.27, P 0.020). In the
subgroup analysis, MS was also independently associated with idiopathic VTE (OR: 1.71; 95% CI: 1.04 to 2.81,
P 0.033), but not with secondary VTE (OR: 1.43; 95% CI: 0.91 to 2.99, P 0.121). Multivariate analysis demonstrated
that high BMI (OR: 1.70, 95% CI: 1.01 to 2.87), decreased HDL cholesterol (OR: 1.99, 95% CI: 1.17 to 3.39), and
elevated fasting glucose levels (OR: 2.31; 95% CI: 1.35 to 3.94) were associated with idiopathic VTE.
Conclusion—MS is associated with VTE and in particular with idiopathic VTE in the Korean population. (Arterioscler
Thromb Vasc Biol. 2009;29:311-315.)
Key Words: venous thromboembolism metabolic syndrome
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