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Inducible nitric oxide mediates systemic microvascular leak following acid aspiration and mechanical ventilation

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Author(s)
Won-Il ChoiDeborah A QuinnKun Young KwonKwon Moo ParkJeong Wook SeoOlga SyrkinaCristhiaan D OchoaJoseph V BonventreCharles A Hales
Keimyung Author(s)
Choi, Won IlKwon, Kun Young
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Journal Title
Basic and Applied Pathology
Issued Date
2008
Volume
1
Issue
1
Abstract
Background and aims: The systemic effects associated with mechanical venti-
lation of lungs injured by hydrochloric acid (HCl) aspiration are unexplored. We
hypothesize that low dose acid aspiration will predispose the lung and the kidney
to damage from large tidal volumes through activation of inducible nitric oxide syn-
thase (iNOS). Materials and methods: Hydrochloric acid (HCl; pH 1.25, 1 mL/kg ),
or an equal amount of 0.9% sodium chloride (NaCl), were inserted into the tra-
chea of rats immediately prior to mechanical ventilation. Rats were then ventilated
with room air at 85 breaths per minute for 2 hours, either with a tidal volume (V
T
)of
7 mL/kg or 14 mL/kg (V
T
7, V
T
14) and zero end expiratory pressure. Kidney microvas-
cular leak, which was assessed by measuring urine protein over 24 hours and by
Evans blue dye (EBD) technique, was used as an indicator of systemic microvascu-
lar leak. Results: A significant microvascular leak occurred in both lung and kidney
exposed to V
T
14 with HCl compared to those exposed to either V
T
7withHClor
the NaCl control group. iNOS activity was significantly increased in the lung and the
kidney tissue in V
T
14 with acid aspiration. The relatively selective iNOS inhibitor,
L-N6-(1-iminoethyl)lysine (L-NIL), attenuated the EBD microvascular leak in lung and
kidney and the proteinuria in the V
T
14 with acid aspiration group. Conclusion: iNOS
may have mediated the systemic microvascular leak in the present model.
Keimyung Author(s)(Kor)
최원일
권건영
Publisher
School of Medicine
Citation
Won-Il Choi et al. (2008). Inducible nitric oxide mediates systemic microvascular leak following acid
aspiration and mechanical ventilation. Basic and Applied Pathology, 1(1), 23–29. doi: 10.1111/j.1755-9294.2008.00005.x
Type
Article
ISSN
1755-9294
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1755-9294.2008.00005.x
DOI
10.1111/j.1755-9294.2008.00005.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35143
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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