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FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma

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Author(s)
Dong Hwan KimHee Du JungJong Gwang KimJe-Jung LeeDeok-Hwan YangYeon Hee ParkYoung Rok DoHo Jin ShinMin Kyoung KimMyung Soo HyunSang Kyun Sohn
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Blood
Issued Date
2006
Volume
108
Issue
8
Abstract
The precise mechanism of rituximab plus cyclophosphamide/doxorubicin/vincristine/prednisone (R-CHOP) therapy in diffuse large B-cell lymphoma (DLBCL) is not fully elucidated. Besides overcoming bcl-2-mediated chemoresistance, antibody-dependent cellular cytotoxicity (ADCC), which is activated by effector cells via immunoglobulin G (IgG) fragment C receptors (FcRs), was also proposed as a mechanism of rituximab. The current study evaluated the impact of FcR polymorphism on the response to R-CHOP therapy for DLBCL with the basis that FcR polymorphism can affect rituximab's affinity for ADCC effector cells. The FCGR3A and FCGR2A gene polymorphisms were determined in DLBCL patients receiving R-CHOP (n = 113) compared with CHOP therapy (n = 85). The FCGR3A valine (V) allele was significantly correlated with a higher complete response rate to R-CHOP compared with the phenylalanine (F) allele (88% in V/V vs 79% in V/F vs 50% in F/F; P = .002), while no difference was found between FCGR2A polymorphisms. In addition, V/V allele was associated with faster achievement of response than other alleles. The impact of the FCGR3A gene polymorphism on response rate was not noted in the CHOP group. In terms of overall or event-free survival, no difference was found according to FCGR3A or FCGR2A alleles. The FCGR3A single nucleotide polymorphism (SNP) is predictive of response to R-CHOP, but does not correlate with survival in patients with DLBCL.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine
Citation
Dong Hwan Kim et al. (2006). FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma. Blood, 108(8), 2720–2725. doi: 10.1182/blood-2006-01-009480
Type
Article
ISSN
0006-4971
DOI
10.1182/blood-2006-01-009480
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35225
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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