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Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells

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Author(s)
Sung Ok KimByung Tae ChoiIl-Whan ChoiJaehun CheongGi-Young KimTaeg Kyu KwonNam Deuk KimYung Hyun Choi
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
BMB Reports
Issued Date
2009
Volume
42
Issue
10
Abstract
The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibitors such as trichostatin A and sodium butyrate inhibited cell migration and invasion. HDAC inhibitors markedly induced Egr-1 expression during the early period, after which expression levels decreased. In addition, the down-regulation of snail and type 1 insulin-like growth factor receptor (IGF-1R) in HDAC inhibitor-treated cells induced the upregulation of thrombospondin-1 (TSP-1), E-cadherin and claudin-3. Cells transfected with Egr-1 and claudin-3 siRNA displayed significant blockage of HDAC inhibitor-induced anti-invasive activity. Collectively, these findings indicate that the up-regulation of Egr-1 and claudin-3 are crucial steps in HDAC inhibitor-induced anti-metastasis and anti-invasion.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Sung Ok Kim et al. (2009). Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells. BMB Reports, 42(10), 655–660.
Type
Article
ISSN
1976-6696
Source
http://www.bmbreports.org/journal/view.html?volume=42&number=10&spage=655
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35233
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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