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KNOW-KT (KoreaN cohort study for outcome in patients with kidney transplantation: a 9-year longitudinal cohort study): study rationale and methodology

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Author(s)
Jaeseok YangJoongyup LeeKyu Ha HuhJae Berm ParkJang-Hee ChoSik LeeHan RoSeung-Yeup HanYoung Hoon KimJong Cheol JeongByung-Joo ParkDuck Jong HanSung-Bae ParkWookyung ChungSung Kwang ParkChan-Duck KimSung Joo KimYu Seun KimCurie AhnKNOW-KT Study Group
Keimyung Author(s)
Han, Seung YeupPark, Sung Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
BMC Nephrology
Issued Date
2014
Volume
15
Issue
1
Abstract
Background : Asian patients undergoing kidney transplantation (KT) generally have better renal allograft survival and a lower burden of cardiovascular disease than those of other racial groups. The KNOW-KT aims to explore allograft survival rate, cardiovascular events, and metabolic profiles and to elucidate the risk factors in Korean KT patients.
Methods : KNOW-KT is a multicenter, observational cohort study encompassing 8 transplant centers in the Republic of Korea. KNOW-KT will enroll 1,000 KT recipients between 2012 and 2015 and follow them up to 9 years. At the time of KT and at pre-specified intervals, clinical information, laboratory test results, and functional and imaging studies on cardiovascular disease and metabolic complications will be recorded. Comorbid status will be assessed by the age-adjusted Charlson co-morbidity index. Medication adherence and information on quality of life (QoL) will be monitored periodically. The QoL will be assessed by the Kidney Disease Quality of Life Short Form. Donors will include both living donors and deceased donors whose status will be assessed by the Kidney Donor Risk Index. Primary endpoints include graft loss and patient mortality. Secondary endpoints include renal functional deterioration (a decrease in eGFR to <30 mL/min/1.73 m2), acute rejection, cardiovascular event, albuminuria, new-onset diabetes after transplant, and QoL. Data on other adverse outcomes including episodes of infection, malignancy, recurrence of original renal disease, fracture, and hospitalization will also be collected. A bio-bank has been established for the acquisition of DNA, RNA, and protein from serum and urine samples of recipients at regular intervals. Bio-samples from donors will also be collected at the time of KT. KNOW-KT was registered in an international clinical trial registry (NCT02042963 at http://​www.​clinicaltrials.​gov) on January 20th, 2014.
Conclusion : The KNOW-KT, the first large-scale cohort study in Asian KT patients, is expected to represent the Asian KT population and provide information on their natural course, complications, and risk factors for complications.
Keywords : Cohort study – Complication – Kidney transplantation – KNOW-KT – Risk factor
Keimyung Author(s)(Kor)
한승엽
박성배
Publisher
School of Medicine
Citation
Jaeseok Yang et al. (2014). KNOW-KT (KoreaN cohort study for outcome in
patients with kidney transplantation: a 9-year
longitudinal cohort study): study rationale and
methodology. BMC Nephrology, 15(1), 77–77. doi: 10.1186/1471-2369-15-77
Type
Article
ISSN
1471-2369
DOI
10.1186/1471-2369-15-77
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35244
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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