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Eleven years of experience with the neurologic complications in Korean patients with acute aortic dissection: a retrospective study

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Author(s)
Seung-Jae LeeJae-Hyun KimChan-Young NaSam-Sae OhYang-Min KimChang-Keun LeeDal-Soo Lim
Keimyung Author(s)
Kim, Jae HyunNa, Chan Young
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
BMC Neurology
Issued Date
2013
Volume
13
Issue
1
Abstract
Background : This study attempts to explore the clinical features, possible mechanisms and prognosis of the neurologic complications in patients with acute aortic dissection (AD).
Methods : Medical records of 278 consecutive patients with AD (165 with type A and 113 with type B dissection) over 11.5 years were retrospectively analyzed for clinical history, CT findings, neurologic complications and outcome. Neurologic complications were classified into early-onset or delayed-onset complications. Independent t-test or Chi-square test (or Fisher exact test) was used for comparing the different groups. Multivariable logistic regression analysis was performed to determine the independent association between variables.
Results : The mean age of the included patients (145 male and 133 female) was 59.4 years (range 19–91 years). 41 patients (14.7%) had a neurologic complication, which included 21 with early-onset complication and 23 with delayed-onset complication, including 3 with both. Advanced age and classic type of dissection were independently associated with the neurologic complication in patients with type A dissection. The most frequent manifestation was ischemic stroke (26 patients, 9.4%), followed by hypoxic encephalopathy (9, 3.2%), ischemic neuropathy (5, 1.8%), spinal cord ischemia (5, 1.8%), seizure (2, 0.7%), hoarseness (1, 0.4%) and septic encephalopathy (1, 0.4%). Overall in-hospital mortality was 10.1%, whereas the complicated group had a mortality rate of 43.9%. Renal impairment, pulse deficit, neurologic complication and nonsurgical treatment were independent variables for determining in-hospital mortality in patients with type A dissection.
Conclusions : The dominance of neurologic symptom in the early stage of AD may make its early diagnosis difficult. Besides chest pain and widened mediastinum in chest x-ray, variable neurologic symptoms including left hemiparesis with asymmetric pulse and hypotension may suggest underlying AD.
Keimyung Author(s)(Kor)
김재현
나찬영
Publisher
School of Medicine
Citation
Seung-Jae Lee et al. (2013). Eleven years of experience with the neurologic complications in Korean patients with acute aortic dissection: a retrospective study. BMC Neurology, 13(1), 46–46. doi: 10.1186/1471-2377-13-46
Type
Article
ISSN
1471-2377
DOI
10.1186/1471-2377-13-46
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35246
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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