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TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin

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Author(s)
Jong Gwang KimSang Kyun SohnYee Soo ChaeHong Suk SongKi-Young KwonYoung Rok DoMin Kyoung KimKyung Hee LeeMyung Soo HyunWon Sik LeeChang-Hak SohnJoo Seop JungGab Chul KimHo Young ChungWansik Yu
Keimyung Author(s)
Song, Hong SukKwon, Ki YoungDo, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Chemotherapy and Pharmacology
Issued Date
2009
Volume
64
Issue
2
Abstract
Purpose : The present study analyzed the polymorphisms of apoptosis-related genes and their impact on the response to chemotherapy and survival of patients with advanced gastric cancer.
Patients and methods : Fifty-seven patients with advanced gastric cancer treated with paclitaxel and cisplatin combination chemotherapy were enrolled in the present study. The genomic DNA was extracted from paraffin-embedded tissue, and the single nucleotide polymorphisms (SNPs) of ten apoptosis-related genes [LTA, TP53, BCL2L11, BID, FASL, caspase 3, caspase 6, caspase 7, and caspase 9] determined using a polymerase chain reaction–restriction fragment length polymorphism assay.
Results : The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis. A multivariate survival analysis also showed that the time to progression for the patients with the Arg/Pro and Pro/Pro genotypes of TP53 codon 72 was worse than for the patients with the Arg/Arg genotype (Hazard ratio = 3.056, P-value = 0.047), whereas the overall survival was not significantly different.
Conclusion : The TP53 codon 72 SNP was found to be predictive of the response to chemotherapy and correlate with the time to progression in patients with advanced gastric cancer treated with paclitaxel and cisplatin chemotherapy.
Keywords : Gastric cancer – Chemotherapy – TP53 – Polymorphism
Keimyung Author(s)(Kor)
송홍석
권기영
도영록
Publisher
School of Medicine
Citation
Jong Gwang Kim et al. (2009). TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin. Cancer Chemotherapy and Pharmacology, 64(2), 355–360. doi: 10.1007/s00280-008-0879-3
Type
Article
ISSN
0344-5704
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs00280-008-0879-3
DOI
10.1007/s00280-008-0879-3
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35298
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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