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Mitochondrial microsatellite instability in gastric cancer and gastric epithelial dysplasia as a precancerous lesion

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Author(s)
Chang-Wook JeongJae-Ho LeeSoo-Sang SohnSeung-Wan RyuDae-Kwang Kim
Keimyung Author(s)
Lee, Jae HoKim, Dae KwangSohn, Soo SangRyu, Seung Wan
Department
Dept. of Anatomy (해부학)
Dept. of Medical Genetics (의학유전학)
Dept. of Surgery (외과학)
Institute for Cancer Research (암연구소)
Journal Title
Cancer Epidemiology
Issued Date
2010
Volume
34
Issue
3
Abstract
Background: Genetic instability in gastric cancer represents a key molecular step that occurs early in the carcinogenesis process. To clarify the role of genetic instability in the progression from gastric dysplasia to gastric cancer, mitochondrial microsatellite instability (mtMSI) was studied in gastric cancer and gastric dysplasia. Methods: DNA was isolated from paired normal and tumoral tissues in 24 patients with gastric dysplasia (low grade) and 49 patients with gastric cancer. mtMSI was analyzed using eight microsatellite markers. mtMSI in gastric dysplasia was studied prospectively to elucidate the relation between mtMSI and gastric carcinogenesis. Results: mtMSI was found in 5 (10.2%) of 49 gastric cancer patients. The mtMSI phenotype was not associated with age, gender, and Helicobacter pylori infection. However, all of the mtMSI was found in intestinal-type gastric cancer (20.8%, p = 0.02). In gastric dysplasia, mtMSI was detected in 3 (12.5%) of 24 patients with gastric dysplasia. mtMSI-positive gastric dysplasia showed a poor prognosis statistically compared to mtMSI negative through progression to high-grade dysplasia or gastric cancer. Conclusions: These data suggest that mtMSI may be an early and important event in the progression of gastric carcinogenesis, especially in intestinal-type gastric cancer.

Abbreviations
ATP, adenosine-5′-triphosphate;
COI, cytochrome oxidase subunit 1;
mtDNA, mitochondrial DNA;
mtMSI, mitochondrial microsatellite instability;
nMSI, nuclear microsatellite instability;
OXPHOS, oxidative phosphorylation;
ROS, reactive oxygen species
Keywords
Gastric cancer;
Gastric dysplasia;
Genetic instability;
Mitochondrial microsatellite instability
Keimyung Author(s)(Kor)
이재호
김대광
손수상
류승완
Publisher
School of Medicine
Citation
Chang-Wook Jeong et al. (2010). Mitochondrial microsatellite instability in gastric cancer and gastric epithelial dysplasia as a precancerous lesion. Cancer Epidemiology, 34(3), 323–327. doi: 10.1016/j.canep.2010.03.015
Type
Article
ISSN
1877-7821
Source
https://www.sciencedirect.com/science/article/pii/S187778211000055X?via%3Dihub
DOI
10.1016/j.canep.2010.03.015
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35301
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
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