계명대학교 의학도서관 Repository

No association between dinucleotide repeat polymorphism in intron 1 of the epidermal growth factor receptor gene EGFR and risk of lung cancer

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Author(s)
Su Jeong LeeKyung Mee KimMyung Hwa ChaeWon Kee LeeSin KamSung Ick ChaHyung Soo HanChang Ho KimYoung Mo KangSung Beom HanJae Yong Park
Keimyung Author(s)
Han, Sung Beom
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Genetics and Cytogenetics
Issued Date
2007
Volume
172
Issue
1
Abstract
The tyrosine kinase receptor EGFR pathway is one of the oncogenic signaling cascades involved in lung cancer, mediating the epidermal growth factor receptor gene EGFR. First-intron polymorphisms with greater numbers of CA dinucleotide repeats tend to downregulate EGFR expression, which suggests that this polymorphism may modulate susceptibility to lung cancer. The present hospital-based case–control study evaluated the possible association of CA repeat polymorphism in the EGFR gene with risk of lung cancer in a Korean population. A bimodal pattern appeared, with a frequency of 57.1% for 20 CA repeats and 18.6% for 16 CA repeats. There was, however, no significant difference in distribution of allele genotypes between all lung cancer cases and the controls, nor among histological types for the cases.
Keimyung Author(s)(Kor)
한승범
Publisher
School of Medicine
Citation
Su Jeong Lee et al. (2007). No association between dinucleotide repeat polymorphism in intron 1 of the epidermal growth factor receptor gene EGFR and risk of lung cancer. Cancer Genetics and Cytogenetics, 172(1), 29–32. doi: 10.1016/j.cancergencyto.2006.07.012
Type
Article
ISSN
0165-4608
Source
https://www.sciencedirect.com/science/article/pii/S016546080600505X?via%3Dihub
DOI
10.1016/j.cancergencyto.2006.07.012
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35309
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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