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Role of COX-2 in tumor progression and survival of head and neck squamous cell carcinoma

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Author(s)
and Dong M. ShinNabil F. SabaMisun ChoiSusan MullerHyung Ju C. ShinMourad TighiouartVassiliki A PapadimitrakopoulouAdel K El-NaggarFadlo R. KhuriZhuo (Georgia) Chen
Keimyung Author(s)
Choe, Mi Sun
Department
Dept. of Pathology (병리학)
Journal Title
Cancer Prevention Research
Issued Date
2009
Volume
2
Issue
9
Abstract
Inhibition of cyclooxygenase-2 (COX-2) pathways may have significant implications for the prevention and treatment of head and neck squamous cell carcinoma (HNSCC). COX-2 is overexpressed in both premalignant lesions and invasive HNSCC. We examined COX-2 expression by immunohistochemistry in normal tissues, different stages of premalignant lesions, and carcinoma in situ (CIS). We also evaluated the correlation between COX-2 expression and clinical characteristics of HNSCC patients. Tissue specimens were obtained from the following: premalignant lesions from 25 subjects enrolled in a biochemoprevention trial, tumor samples collected at diagnosis from 38 HNSCC patients enrolled in an induction chemotherapy trial, and normal control tissues from 10 noncancer, nonsmoking subjects. COX-2 was expressed in early and intermediate stages of premalignant lesions, increasing first in the basal and parabasal layers, then lower spinous, and upper spinous layers. This correlation was noted in normal epithelium (P < 0.0001), histologically normal in-field samples (P < 0.0001), low-grade dysplasia (P = 0.024), and moderate-grade dysplasia (P = 0.009), but was lost in the majority of high-grade dysplasia/CIS (P = 0.896). COX-2 expression was also noted to increase progressively through the early stages of premalignancy, and to decrease in severe/CIS stage and invasive carcinoma. COX-2 expression in tumors from patients treated with induction chemotherapy was correlated with overall survival after controlling for clinical variables. These findings elucidate the differential expression pattern of COX-2 in stages of head and neck premalignant lesions and invasive carcinoma, supporting the rationale for COX-2 inhibition as an important strategy for cancer chemoprevention. Further validation of COX-2 expression is needed in prospective ongoing chemoprevention trials.
Keywords COX-2
head and neck cancer
premalignancy
chemoprevention
cyclooxygenase 2
Keimyung Author(s)(Kor)
최미선
Publisher
School of Medicine
Citation
and Dong M. Shin et al. (2009). Role of COX-2 in tumor progression and survival of head and neck squamous cell carcinoma. Cancer Prevention Research, 2(9), 823–829. doi: 10.1158%2F1940-6207.CAPR-09-0077
Type
Article
ISSN
1940-6207
Source
http://cancerpreventionresearch.aacrjournals.org/content/2/9/823
DOI
10.1158%2F1940-6207.CAPR-09-0077
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35328
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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