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Multicenter Validation Study of a Prognostic Index for Portal Vein Tumor Thrombosis in Hepatocellular Carcinoma

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Author(s)
Jeong Il YuSang Min YoonHee Chul ParkJong Hoon KimTae Hyun KimJoong-Won ParkJinsil SeongIk Jae LeeHong Seok JangChul Seung KayChul Yong KimEui Kyu ChieJin Hee KimMi-Sook KimYoung Min Choi
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Cancer Research and Treatment
Issued Date
2014
Volume
46
Issue
4
Abstract
Purpose : We previously reported on a staging system and prognostic index (PITH) for portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT) at a single institution. The aim of this study is to validate the PITH staging system using data from patients at other institutions and to compare it with other published staging systems.
Materials and Methods : A total of 994 HCC patients with PVTT who were treated with RT between 1998 and 2011 by the Korean Radiation Oncology Group were analyzed retrospectively. All patients were staged using the Cancer of the Liver Italian Program (CLIP), Japanese Integrated Staging (JIS), Okuda, and PITH staging systems, and survival data were analyzed. The likelihood ratio, Akaike information criteria (AIC), time-dependent receiver operating characteristics, and prediction error curve analysis were used to determine discriminatory ability for comparison of staging systems.
Results : The median survival was 9.2 months. Compared with the other staging systems, the PITH score gave the highest values for likelihood ratio and lowest AIC values, demonstrating that PITH may be a better prognostic model. Although the values were not significant and differences were not exceptional, the PITH score showed slightly better performance with respect to time-dependent area under curve and integrated Brier score of prediction error curve.
Conclusion : The PITH staging system was validated in this multicenter retrospective study and showed better stratification ability in HCC patients with PVTT than other systems.
Key words: Hepatocellular carcinoma, Portal vein, Radiotherapy, Multicenter study, Validation
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine
Citation
Jeong Il Yu et al. (2014). Multicenter Validation Study of a Prognostic Index for Portal Vein Tumor Thrombosis in Hepatocellular Carcinoma. Cancer Research and Treatment, 46(4), 348–357. doi: 10.4143/crt.2013.142
Type
Article
ISSN
1598-2998
DOI
10.4143/crt.2013.142
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35331
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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