계명대학교 의학도서관 Repository

Interval between Surgery and Radiation Therapy Is an Important Prognostic Factor in Treatment of Rectal Cancer

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Author(s)
Jin Hee KimSang Jun ByunSeung Gyu ParkYoung Kee OhSeong Kyu Baek
Keimyung Author(s)
Baek, Seong KyuKim, Jin HeeOh, Young Kee
Department
Dept. of Surgery (외과학)
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Cancer Research and Treatment
Issued Date
2012
Volume
44
Issue
3
Abstract
Purpose : The purpose of this study is to evaluate survival and prognostic factors for rectal cancer, including interval between surgery and radiation therapy after surgery, radiation therapy, and chemotherapy.

Materials and Methods : We conducted a retrospective study of 153 patients with rectal cancer who were treated with surgery, radiotherapy with/without chemotherapy at Keimyung University Dongsan Medical Center from January, 1988 to December, 2005. The study included 89 males and 64 females, with a median age of 56 years (range, 23 to 81 years). Tumor, node and metastasis (TNM) was I in 23 patients, II in 39, and III in 91. Radiation therapy was performed on pelvic fields using a median dose of 54 Gy five days per week, 1.8 Gy once per day. Ninety two patients were treated with radiotherapy, 43 with concurrent chemo-radiation therapy and 18 with sequential therapy after surgery. The median follow-up period was 52 months (range, 4 to 272 months). The interval between surgery and radiation was 1-25 weeks (median, 5 weeks).

Results : Two-year and five-year overall survival rate was 64.7% and 46.4%, respectively. Two-year and five-year disease-free-survival (DFS) rate was 58.6% and 43.1%, respectively. Median DFS was 39 months. Loco-regional failure was evident in 10.5% of patients, 8.4% had distant metastasis, and 9.2% had both. In multivariate analysis, TNM stage and interval between surgery and radiation therapy (≤5 weeks vs. >5 weeks; 95% confidence interval, 1.276 to 2.877; hazard ratio, 1.916; p=0.002) were significant prognostic factors of DFS.

Conclusion : Survival rates for rectal cancer after surgery, chemotherapy, and radiation therapy were similar to those reported in previous studies. Starting radiation therapy as soon as possible after surgery, especially within the first five weeks after surgery, is suggested.

Key words: Rectal neoplasms, Adjuvant radiotherapy, Drug therapy, Prognosis
Keimyung Author(s)(Kor)
백성규
김진희
오영기
Publisher
School of Medicine
Citation
Jin Hee Kim et al. (2012). Interval between Surgery and Radiation Therapy Is an Important Prognostic Factor in Treatment of Rectal Cancer. Cancer Research and Treatment, 44(3), 187–194. doi: 10.4143/crt.2012.44.3.187
Type
Article
ISSN
1598-2998
DOI
10.4143/crt.2012.44.3.187
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35346
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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