계명대학교 의학도서관 Repository

Metachronous Double Primary Cancer after Treatment of Breast Cancer

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Author(s)
Jin Young KimHong Suk Song
Keimyung Author(s)
Kim, Jin YoungSong, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Research and Treatment
Issued Date
2015
Volume
47
Issue
1
Abstract
Purpose : The pattern of double primary cancer after treatment for breast cancer is important for patient survival.

Materials and Methods : We analyzed 108 cases of metachronous double primary cancer in breast cancer patients treated from 1999 to 2012.

Results : Metachronous double primary cancers occurred in 108 of 2,657 patients (4.1%) with breast cancer. The median time to the occurrence of second cancer after diagnosis of the first was 58.4±41.2 months (range, 6.9 to 180.2 months). The most common cancer was thyroid cancer, which occurred in 45 patients (41.7%). This was followed by gastric cancer in 16 patients (14.8%), endometrial cancer in 10 patients (9.3%), and cervical cancer in seven patients (6.5%). The relative risk showed a significant increase in endometrial (4.78; 95% confidence interval [CI], 1.66 to 13.79), gastric (2.61; 95% CI, 1.68 to 4.06), and thyroid cancer (1.95; 95% CI, 1.37 to 2.79). At 5 years after diagnosis of breast cancer, secondary cancer occurred in 48 patients (44.4%), with 50.0% of the endometrial, 56.3% of the stomach, and 37.8% of the thyroid cancer cases being diagnosed after 5 years. Median survival after diagnosis of the second cancer was 123.9±11.2 months. The prognosis was mainly influenced by the anatomic site.

Conclusion : The incidence of endometrial, stomach, and thyroid cancer increased significantly after treatment with primary breast cancer, and survival was dependent on early detection and the type of second primary cancer. A prolonged follow-up examination for metachronous double primary cancer is needed to provide early detection and improve survival time in patients with breast cancer.

Key words: Breast neoplasms, Second primary neoplasms, Diagnosis
Keimyung Author(s)(Kor)
김진영
송홍석
Publisher
School of Medicine
Citation
Jin Young Kim and Hong Suk Song. (2015). Metachronous Double Primary Cancer after Treatment of Breast Cancer. Cancer Research and Treatment, 47(1), 64–71. doi: 10.4143/crt.2013.215
Type
Article
ISSN
1598-2998
DOI
10.4143/crt.2013.215
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35347
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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