계명대학교 의학도서관 Repository

Comparison of Biolimus A9–Eluting (Nobori) and Everolimus-Eluting (Promus Element) Stents in Patients With De Novo Native Long Coronary Artery Lesions A Randomized Long Drug-Eluting Stent V Trial

Metadata Downloads
Author(s)
Jong-Young LeeDuk-Woo ParkYoung-Hak KimJung-Min AhnWon-Jang KimSoo-Jin KangSeung-Whan LeeCheol Whan LeeSeong-Wook ParkSung-Cheol YunTae-Hyun YangBong-Ki LeeNae-Hee LeeJoo-Young YangWon-Yong ShinHun Sik ParkKee-Sik KimSeung Ho HurSung Yun LeeJong-Seon ParkYun Seok ChoiSeung Uk LeeSung-Ho HerSeung-Jung Park
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Circulation: Cardiovascular Interventions
Issued Date
2014
Volume
7
Issue
3
Abstract
Background—Procedural and clinical outcomes still remain unfavorable for patients with long coronary lesions who undergo percutaneous coronary intervention. The current study, therefore, evaluated 2 innovative drug-eluting stents for the management of long-lesion coronary artery disease.


Methods and Results—This randomized, multicenter, prospective trial, called the Long Drug-Eluting Stent (LONG-DES) V trial, compared the biodegradable polymer–based biolimus A9–eluting stent (BES) and the durable polymer–based platinum chromium everolimus-eluting stent (PtCr-EES) in 500 patients with long (≥25 mm) coronary lesions. The primary end point of the trial was in-segment late luminal loss at the 9-month angiographic follow-up. The BES and PtCr-EES groups had similar baseline characteristics, with a slightly shorter lesion length in the BES group versus the PtCr-EES group (29.24±12.17 versus 32.27±13.84 mm; P=0.016). In-segment late luminal loss was comparable between the 2 groups at the 9-month angiographic follow-up (BES, 0.14±0.38 versus PtCr-EES, 0.11±0.37 mm; difference, 0.031; 95% confidence interval, −0.053 to 0.091; P=0.03 for a noninferiority margin of 0.11, P=0.45 for superiority), as was in-stent late luminal loss (0.20±0.41 versus 0.24±0.38 mm; P=0.29). The incidence of in-segment (6.1% versus 4.9%; P=0.63) and in-stent (3.7% versus 4.9%; P=0.59) binary restenosis was also similar between the groups. There was no significant between-group difference in the rate of composite outcome of death, myocardial infarction, and target vessel revascularization (41, 16.7% in BES versus 42, 16.5% in PtCr-EES; P=0.94).


Conclusions—BES and PtCr-EES implantation showed analogous angiographic and clinical outcomes for patients with de novo long coronary lesions.


Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01186120.
Key Words: angioplasty
biolimus
coronary artery disease
everolimus
stents
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Jong-Young Lee et al. (2014). Comparison of Biolimus A9–Eluting (Nobori) and Everolimus-Eluting (Promus Element) Stents in Patients With De Novo Native Long Coronary Artery Lesions A Randomized Long Drug-Eluting Stent V Trial. Circulation: Cardiovascular Interventions, 7(3), 322–329. doi: 10.1161/CIRCINTERVENTIONS.113.000841
Type
Article
ISSN
1941-7640
DOI
10.1161/CIRCINTERVENTIONS.113.000841
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35412
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.