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Prognostic Implications of the NT-ProBNP Level and Left Atrial Size in Non-Ischemic Dilated Cardiomyopathy

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Author(s)
Hyungseop KimYun-Kyeong ChoDong-Hwan JunChang-Wook NamSeong-Wook HanSeung-Ho HurYoon-Nyun KimKwon-Bae Kim
Keimyung Author(s)
Kim, Hyung SeopCho, Yun KyeongNam, Chang WookHan, Seong WookHur, Seung HoKim, Yoon NyunKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Circulation Journal
Issued Date
2008
Volume
72
Issue
10
Abstract
Background The ratio of peak early diastolic mitral inflow to annular velocity (E/E') and left atrial size could provide prognosis on congestive heart failure (CHF). N-terminal Pro B-type natriuretic peptide (NT-ProBNP) has also been useful for predicting adverse cardiac events. However, it is not clear how these parameters compare with conventional risk factors. Thus, we investigated whether E/E', left atrial dimension index (LADI) and NT-ProBNP would predict adverse events and add incremental value to conventional risk factors, even in non-ischemic advanced dilated cardiomyopathy (DCM). Methods and Results Both NT-ProBNP and echocardiography were evaluated in 105 patients. The cardiac events were defined as the composite of cardiac death and re-admission for CHF. At follow up, cardiac events occurred in 24 patients who had high NT-ProBNP and showed higher LADI and E/E'. In multivariate analysis, both NT-ProBNP and LADI, but not E/E', remained as independent predictors; patients with both increased LADI and NT-ProBNP had a 27-fold higher risk of cardiac events than those without any risk factors (p=0.003). Moreover, LADI and NT-ProBNP showed a better incremental prognostic value over conventional risk factors (global chi-square increase from 7 to 17 to 49, p=0.003, p<0.001, respectively). Conclusions Both NT-ProBNP and LADI might have the most predictable power, particularly in non-ischemic advanced DCM.
Keimyung Author(s)(Kor)
김형섭
조윤경
남창욱
한성욱
허승호
김윤년
김권배
Publisher
School of Medicine
Citation
Hyungseop Kim et al. (2008). Prognostic Implications of the NT-ProBNP Level and Left Atrial Size in Non-Ischemic Dilated Cardiomyopathy. Circulation Journal, 72(10), 1658–1665. doi: 10.1253/circj.CJ-07-1087
Type
Article
ISSN
1346-9843
DOI
10.1253/circj.CJ-07-1087
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35429
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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