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Clinical applications of SPECT/CT after first I-131 ablation in patients with differentiated thyroid cancer

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Author(s)
Shin Young JeongSang-Woo LeeHae Won KimBong-Il SongByeong-Cheol AhnJaetae Lee
Keimyung Author(s)
Kim, Hae WonSong, Bong Il
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
Clinical Endocrinology
Issued Date
2014
Volume
81
Issue
3
Abstract
Summary


Objective

This study aimed to determine which thyroid cancer patients would benefit from SPECT/CT in addition to whole-body planar scintigraphy (RxWBS) for the detection and characterization of I-131 focal uptake after first ablation.


Design and Patients

Neck and thoracic SPECT/CT was performed in 187 patients with I-131 focal uptake suggestive of remnant thyroid tissue (Rem group, n = 152) or presumed lymph node (LN) metastases (mLN group, n = 35) on RxWBS. Clinical and pathologic parameters were analysed and compared in patients with and without additional SPECT/CT findings.


Results

wIn the Rem group, SPECT/CT revealed additional occult findings on RxWBS in 13 patients (8·6%). The serum thyroglobulin levels at the time of ablation were significantly higher in patients with additional SPECT/CT findings than in patients without additional findings (4·3 ± 3·4 ng/ml vs 1·6 ± 2·7 ng/ml, P = 0·001). In the mLN group, SPECT/CT demonstrated only remnant thyroid tissues without evidence of lymph node metastasis in 14 (40·0%) patients, whereas in the remaining 21 (60·0%) patients, I-131 uptake was confirmed in the corresponding neck and mediastinal lymph nodes on SPECT/CT.


Conclusions

Even in the Rem group, additional SPECT/CT could provide useful information for detecting hidden metastasis, especially in patients with high serum thyroglobulin levels. SPECT/CT should be recommended for patients with focal uptake lymph node metastasis on RxWBS.
Keimyung Author(s)(Kor)
김해원
송봉일
Publisher
School of Medicine
Citation
Shin Young Jeong et al. (2014). Clinical applications of SPECT/CT after first I-131 ablation in patients with differentiated thyroid cancer. Clinical Endocrinology, 81(3), 445–451. doi: 10.1111/cen.12460
Type
Article
ISSN
0300-0664
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1111/cen.12460
DOI
10.1111/cen.12460
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35445
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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