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Matrix metalloproteinase-1 promoter is associated with body mass index in Korean population with aged greater or equal to 50 years

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Author(s)
Young-Kyun NhoEunyoung HaKyung-Im YuJoo-Ho ChungNam-Chang WookIn-Sung ChungMi-Young LeeDong-Hoon Shin
Keimyung Author(s)
Chung, In SungLee, Mi YoungShin, Dong HoonHa, Eun YoungNam, Chang Wook
Department
Dept. of Preventive Medicine (예방의학)
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Institute for Cancer Research (암연구소)
Journal Title
Clinical Chimica Acta
Issued Date
2008
Volume
396
Issue
1-2
Abstract
Background

Obesity leads to serious medical complications and impairment of quality of life. We investigated whether inter-individual variability in the risk of obesity was associated with a crucial fibrillar collagen-degrading enzyme matrix metalloproteinase (MMP)-1 polymorphisms (MMP1-1607 and MMP1-519).

Methods

A population-based cohort study consisting of 530 subjects was performed. Body mass index (BMI), systolic and diastolic blood pressures, fasting blood sugar (FBS), HbA1c, total cholesterol, triglyceride, and high density lipoprotein (HDL)-cholesterol were measured. Study subjects divided into 2 groups, one with BMI < 25.0 and the other with BMI ≥ 25.0, were genotyped for MMP1-1607 and MMP1-519 polymorphisms by pyrosequencing analysis.

Results

Analyses of genotype distributions and allele frequencies revealed that both MMP1-1607 and MMP1-519 polymorphisms were associated with BMI (P = 0.041 and 0.043, respectively) in individuals with age ≥ 50 years. We also observed significantly lower BMI and triglyceride in -519 AA individuals with age ≥ 50 years than in -519 G allele carriers with age ≥ 50 years. Logistic regression analysis revealed that the odds ratio (OR) for increase in BMI associated with the G vs. A allele in individuals with age ≥ 50 was 2.02 [95% confidence interval (CI), 1.13–3.60, P = 0.01], which strongly implicates protective role of MMP1-519 A allele against increase in BMI.

Conclusion

The frequencies of MMP1-1607 G allele and MMP1-519 A allele are significantly higher in subjects with BMI < 25.0 and age ≥ 50 years, suggesting protective roles of MMP1-1607 G allele and MMP1-519 A allele against increase in BMI in Korean population.

Keywords
Obesity;
Matrix metalloproteinase;
Polymorphism
Keimyung Author(s)(Kor)
정인성
이미영
신동훈
하은영
남창욱
Publisher
School of Medicine
Citation
Young-Kyun Nho et al. (2008). Matrix metalloproteinase-1 promoter is associated with body mass index in Korean population with aged greater or equal to 50 years. Clinical Chimica Acta, 396(1–2), 14–17. doi: 10.1016/j.cca.2008.06.012
Type
Article
ISSN
0009-8981
Source
https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(08)00315-X
DOI
10.1016/j.cca.2008.06.012
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35459
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
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