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Long-Term Clinical Outcomes After Angiographically Defined Very Late Stent Thrombosis of Drug-Eluting Stent

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Author(s)
Ung KimDong-Kie KimYoung-Bok KimSang-Hoon SeolTae-Hyun YangDae-Kyeong KimDoo-Il KimDong-Soo KimSang-Hee LeeGeu-Ru HongJong-Seon ParkDong-Gu ShinYoung-Jo KimYoon-Kyung ChoHyung-Seop KimChang-Wook NamSeung-Ho HurKwon-Bae Kim
Keimyung Author(s)
Cho, Yun KyeongKim, Hyung SeopNam, Chang WookHur, Seung HoKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Clinical Cardiology
Issued Date
2009
Volume
32
Issue
9
Abstract
Background: The advent of drug-eluting stent (DES) use has raised concerns regarding later occurring stent
thrombosis, especially very late stent thrombosis (VLST), and little is known about long-term clinical outcomes
after VLST occurrence.
Hypothesis: Long-term clinical outcomes after detection of VLST may be poor.
Method: We evaluated 3572 consecutive patients who received DES implantation from May 2004 to July 2007 at
3 hospitals. The primary outcomes were a composite of major adverse cardiac events (MACE) including cardiac
death, myocardial infarction (MI), target-lesion revascularization (TLR), and target-vessel revascularization
(TVR) after VLST occurrence.
Results: We identified 19 patients (0.53%) with angiographically documentedstent thrombosis developingover
1 year after DES implantation. The mean time to VLST occurrence was 899 days (899 ± 353). Discontinuation
of antiplatelet drugs was noted in 4 (21%) patients and the average duration of discontinuation was 4 days.
Clinical presentations of VLST were mainly MI (17 patients, 89%). Balloon angioplasty was only performed in
12 patients (63%) and stent implantation in 7 patients (37%). Mean follow-up duration from VLST occurrence
was 620 days (620 ± 256). During clinical follow-up after VLST occurrence, no cardiac deaths or MIs were
detected. Target-vessel revascularization was done in 2 (11%) patients and TLR in 1 patient (6%). Major
adverse cardiac events occurred in 3 (16%) patients during long-term clinical follow-up.
Conclusions: Clinical presentation of VLST after DES implantation is associated with serious adverse events,
such as MI. Long-term follow-up outcomes after VLST occurrence appear unfavorable and more data from
larger studies are warranted.
Keimyung Author(s)(Kor)
조윤경
김형섭
남창욱
허승호
김권배
Publisher
School of Medicine
Citation
Ung Kim et al. (2009). Long-Term Clinical Outcomes After
Angiographically Defined Very Late Stent
Thrombosis of Drug-Eluting Stent. Clinical Cardiology, 32(9), 526–529. doi: 10.1002/clc.20648
Type
Article
ISSN
0160-9289
DOI
10.1002/clc.20648
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35485
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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