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Spectrum of autonomic dysfunction in orthostatic dizziness

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Author(s)
Hyun-Ah KimHyon-Ah YiHyung Lee
Keimyung Author(s)
Kim, Hyun AhYi, Hyon AhLee, Hyung
Department
Dept. of Neurology (신경과학)
Brain Research Institute (뇌연구소)
Journal Title
Clinical Neurophysiology
Issued Date
2014
Volume
125
Issue
6
Abstract
Objective

To investigate the frequency and detailed spectrum of autonomic dysfunction in patients with orthostatic dizziness (OD).

Methods

Over 20 months, 217 consecutive patients with OD as a presenting symptom of orthostatic intolerance were enrolled. The distribution and severity of autonomic dysfunction were measured by the composite autonomic severity score (CASS), which was derived from a standard autonomic function test including Finapres for recording of the beat-to-beat blood pressure. Sympathetic indexes (SIs) were calculated from the Valsalva maneuver (VM).

Results

Approximately 83% of patients showed at least one abnormal autonomic testing result. We classified OD into 11 groups according to the patterns of autonomic dysfunctions. The most common pattern was generalized autonomic failure of sympathetic adrenergic and parasympathetic cardiovagal functions (n = 60). Patients with delayed OH had larger BP increases during late phase II of the VM (p = 0.04), showed greater phase IV overshoot (p = 0.04), and had a smaller pressure recovery time increase (p = 0.02) than patients with classic OH. Each SI showed the strongest correlation with the CASS adrenergic subscores.

Conclusions

OD can present with a board spectrum of autonomic dysfunctions.

Significance

This investigation could be useful in understanding the pattern and mechanism of autonomic dysfunction associated with OD.

Keywords
Orthostatic dizziness;
Autonomic dysfunction;
Spectrum
Keimyung Author(s)(Kor)
김현아
이현아
이형
Publisher
School of Medicine
Citation
Hyun-Ah Kim et al. (2014). Spectrum of autonomic dysfunction in orthostatic dizziness. Clinical Neurophysiology, 125(6), 1248–1254. doi: 10.1016/j.clinph.2013.10.022
Type
Article
ISSN
1388-2457
Source
https://www.sciencedirect.com/science/article/pii/S1388245713011450?via%3Dihub
DOI
10.1016/j.clinph.2013.10.022
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35499
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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