Uric Acid as Prognostic Marker in Advanced Nonischemic Dilated Cardiomyopathy: Comparison With N-Terminal Pro B-Type Natriuretic Peptide Level

Abstract

Although uric acid (UA) level has been associated with an increased risk of cardiovascular events, it is unclear whether UA can provide greater prognostic information than N-terminal pro B-type natriuretic peptide (NT-proBNP) in advanced heart failure with nonischemic dilated cardiomyopathy (DCM). UA and NT-proBNP values were obtained from a total of 122 DCM patients. Development of clinical events during follow-up was defined as the composite of cardiac death and readmission for heart failure. During follow-up, there were 18 cardiac events. UA and NT-proBNP values were significantly higher in patients with events. The receiver operating characteristics curve showed the area under the curve for UAwas greater than that forNT-proBNP. On multivariate analysis, UA remained the only independent predictor of prognosis. UA concentrations 8.7 mg⁄ dL rather than NT-proBNP 3800 pg⁄mL were associated with significantly decreased event-free survival. The authors’ findings demonstrated that UA value could be an informative predictor in nonischemic DCM