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The Relationship among Homocysteine, Bilirubin, and Diabetic Retinopathy

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Author(s)
Ho Chan Cho
Keimyung Author(s)
Cho, Ho Chan
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes & Metabolism Journal
Issued Date
2011
Volume
35
Issue
6
Abstract
Background: Diabetic retinopathy is a common microvascular complication of diabetes mellitus (DM) and the leading cause of
blindness in adults. Homocysteine, a risk factor with toxic effects on vascular endothelial cells, and bilirubin, a protectant with
antioxidant and anti-inflammatory properties on the vasculature, have been reported to be linked to vaso-occlusive disorders.
Therefore, the author of the present study investigated the association between the levels of plasma homocysteine and serum total
bilirubin and the incidence of diabetic retinopathy as a chronic microvascular complication in patients with type 2 diabetes
mellitus (T2DM).
Methods: A total of 102 patients with T2DM who visited our hospital from January 2009 to January 2010 were assessed.
Results: Of the 102 patients, the prevalence of diabetic retinopathy was 67 cases (65.7%) according to clinical ophthalmic examination.
The duration of DM (P<0.001), age (P=0.003), fasting blood glucose (P=0.045) and urine albumin-creatinine ratio (P=
0.015) in univariate analysis and plasma homocysteine level (P=0.038), duration of DM (P=0.001), and total bilirubin level (P=
0.012) in multiple logistic regression analysis were statistically significantly associated with the incidence of diabetic retinopathy.
Conclusion: The present study indicates that homocysteine and bilirubin may be useful biomarkers for increased risk of diabetic
retinopathy since retinopathy in patients with T2DM was linked to higher plasma homocysteine level and decreased serum
total bilirubin level.
Keywords: Bilirubin; Diabetes mellitus; Homocysteine; Retinopathy
Keimyung Author(s)(Kor)
조호찬
Publisher
School of Medicine
Citation
Ho Chan Cho. (2011). The Relationship among Homocysteine, Bilirubin, and
Diabetic Retinopathy. Diabetes & Metabolism Journal, 35(6), 595–601. doi: 10.4093/dmj.2011.35.6.595
Type
Article
ISSN
2233-6079
DOI
10.4093/dmj.2011.35.6.595
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35573
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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