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Relationship between serum adiponectin and leptin concentrations and body fat distribution

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Author(s)
Keun-Gyu ParkKyong Soo ParkMi-Jung KimHye-Soon KimYoung-Sung SuhJong Doek AhnKwan-Kyu ParkYoung-Chae ChangIn-Kyu Lee
Keimyung Author(s)
Park, Keun GyuKim, Hye SoonLee, In KyuPark, Kwan KyuSuh, Young Sung
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Dept. of Family Medicine (가정의학)
Kidney Institute (신장연구소)
Journal Title
Diabetes Research and Clinical Practice
Issued Date
2004
Volume
63
Issue
2
Abstract
The aim of this study was to investigate the relationship between adiponectin and leptin and body fat distribution. One hundred
and ninety-seven women participated in this study. Subjects were grouped based on their visceral adipose tissue area (VAT).
Body fat distribution was determined by computed tomography. The numbers in the subcutaneous fat dominant group (SFDG)
and visceral fat dominant group (VFDG) were 79 and 118, respectively. The VFDG showed lower adiponectin levels than the
SFDG (8.9 ± 0.4 g/ml versus 11.4 ± 0.7 g/ml, P = 0.006), but leptin levels did not differ significantly between groups
(18.8 ± 1.1 ng/ml versus 17.7 ± 1.8 ng/ml, P = 0.111). Adiponectin levels were inversely correlated with fasting insulin,
HOMA-IR, triglyceride, SBP and DBP, subcutaneous adipose tissue area (SAT) and VAT, and waist-to-hip ratio (WHR). Leptin
levels were positively correlated with fasting glucose and insulin, HOMA-IR, triglyceride, SBP andDBP,VAT andSAT, andWHR
(all values of P < 0.05). VAT and HDL-cholesterol were independent variables of adiponectin concentrations (R2 = 0.207,
P < 0.0001), and SAT, fasting insulin, and HOMA-IR were independent variables of leptin concentrations (R2 = 0.498,
P < 0.0001) In conclusion, adiponectin and leptin concentrations, although associated with metabolic parameters, were more
strongly influenced by VAT in the case of adiponectin, and by SAT in the case of leptin.
© 2003 Elsevier Ireland Ltd. All rights reserved.
Keywords: Adiponectin; Leptin; Visceral adipose tissue; Subcutaneous adipose tissue; Obesity
Keimyung Author(s)(Kor)
박근규
김혜순
이인규
박관규
서영성
Publisher
School of Medicine
Citation
Keun-Gyu Park et al. (2004). Relationship between serum adiponectin and
leptin concentrations and body fat distribution. Diabetes Research and Clinical Practice, 63(2), 135–142. doi: 10.1016/j.diabres.2003.09.010
Type
Article
ISSN
0168-8227
Source
https://www.sciencedirect.com/science/article/pii/S0168822703002523?via%3Dihub
DOI
10.1016/j.diabres.2003.09.010
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35575
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Family Medicine (가정의학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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