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Serum irisin levels in new-onset type 2 diabetes

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Author(s)
Yeon-Kyung ChoiMi-Kyung KimKwi Hyun BaeHyun-Ae SeoJi-Yun JeongWon-Kee LeeJung-Guk KimIn-Kyu LeeKeun-Gyu Park
Keimyung Author(s)
Kim, Mi Kyung
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Research and Clinical Practice
Issued Date
2013
Volume
100
Issue
1
Abstract
Aims: Irisin has been identified as a novel myokine that drives brown-fat-like conversion of
white adipose tissue. In this cross-sectional study, we investigated whether serum irisin
levels are decreased in patients with type 2 diabetes (T2D) compared with control subjects
with normal glucose tolerance (NGT), and assessed the association between serum irisin
levels and various metabolic parameters.
Methods: The study population was selected from a population-based study and included
104 subjects with NGT and 104 subjects with new-onset T2D. Serum irisin and adiponectin
levels and metabolic parameters were measured. Multivariate logistic regression analysis
was performed to assess the association between irisin levels and newly diagnosed T2D.
Results: Serum irisin levels were significantly decreased in the new-onset T2D group
compared with the NGT control group ( p = 0.003). In a multivariable model adjusted for
various metabolic parameters, increased irisin levels were associated with reduced odds (OR
0.64, 95% CI 0.47–0.88, p = 0.006) of prevalent newly diagnosed T2D. Furthermore, multiple
regression analysis showed that 2 h plasma glucose was an independent variable influencing
serum irisin levels ( p = 0.004).
Conclusion: In the present study, we found that serum irisin levels were decreased in T2D
patients and inversely associated with newly diagnosed T2D, suggesting that irisin may play
a crucial role in glucose intolerance and T2D.
Keimyung Author(s)(Kor)
김미경
Publisher
School of Medicine
Citation
Yeon-Kyung Choi et al. (2013). Serum irisin levels in new-onset type 2 diabetes. Diabetes Research and Clinical Practice, 100(1), 96–101. doi: 10.1016/j.diabres.2013.01.007
Type
Article
ISSN
0168-8227
DOI
10.1016/j.diabres.2013.01.007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35576
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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