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The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells

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Author(s)
Hye-Soon KimKeun-Gyu ParkTae Bon KooSeung HuhIn-Kyu Lee
Keimyung Author(s)
Kim, Hye SoonPark, Keun Gyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Research and Clinical Practice
Issued Date
2007
Volume
77S
Issue
3
Abstract
Uncoupling protein 2 (UCP-2) is a newly identified member of the mitochondrial anion carrier family and shares 60% sequence
identity with the well-characterized thermogenic UCP-1 from brown adipose tissue. Several lines of evidence suggest that UCP-2 is
involved in the control of reactive oxygen species (ROS) production by mitochondria. More recently, a direct role for UCP-2 in the
regulation of atherogenesis has been suggested by the observation that bone marrow transplantation from UCP-2-deficient mice to
low-density lipoprotein receptor-deficient mice markedly increased atherosclerotic lesion size. This review introduces the possible
role of UCP-2 in the regulation of atherogenesis in vascular cells. Although the relative contribution of the individual ROS
generating systems in the vasculature is still ambiguous, both cell membrane NAD(P)H oxidase and the mitochondrial electrontransport
chain have been proposed to play significant roles in the overproduction of ROS. UCP-2 can possibly modify
atherosclerotic processes initiated in vascular cells and agents that increase UCP-2 expression in vascular cells may help prevent
the development and progression of atherosclerosis in patients with diabetes or hypertension.
# 2007 Elsevier Ireland Ltd. All rights reserved.
Keimyung Author(s)(Kor)
김혜순
박근규
Publisher
School of Medicine
Citation
Hye-Soon Kim et al. (2007). The modulating effects of the overexpression of uncoupling
protein 2 on the formation of reactive oxygen
species in vascular cells. Diabetes Research and Clinical Practice, 77S(3), S46–S48. doi: 10.1016/j.diabres.2007.01.032
Type
Article
ISSN
0168-8227
Source
https://www.sciencedirect.com/science/article/pii/S0168822707001623?via%3Dihub
DOI
10.1016/j.diabres.2007.01.032
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35578
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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