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Prevention and treatment of macroangiopathy: focusing on oxidative stress

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Affiliated Author(s)
송대규박근규김혜순이인규
Alternative Author(s)
Song, Dae KyuPark, Keun GyuKim, Hye SoonLee, In Kyu
Journal Title
Diabetes Research and Clinical Practice
ISSN
0168-8227
Issued Date
2004
Abstract
Oxidative stress has been proposed to be a major cause of atherosclerosis in diabetes. Endothelial dysfunction, common in
diabetes, is considered a prerequisite for atherosclerosis.We evaluated whether a-lipoic acid (ALA) is an effective treatment for
oxidative stress-induced endothelial dysfunction. Using high resolution ultrasound techniques, we evaluated flow mediated
vasodilation (FMD) of the brachial artery in 13 young healthy men with transient hypertriglyceridemia (HTG) induced by
intralipid infusion and in 11 postmenopausal type 2 diabetics before and after ALA treatment. We also measured superoxide
anion formation in neutrophils as a maker of oxidative stress. FMD was decreased and superoxide anion formation was increased
significantly following intralipid infusion in the young healthy men. ALA treatment, however, reversed the HTG-induced
endothelial dysfunction and decreased the superoxide anion formation. Similarly, treatment with ALA increased FMD and
decreased superoxide anion formation in the postmenopausal type 2 diabetics. In addition, the change in FMD was negatively
correlated with superoxide anion formation in young healthy men and in postmenopausal type 2 diabetics (r = 0.54, 0.65,
respectively). All P values were below 0.05. In conclusion, our results demonstrate that ALA treatment improves HTG- and
diabetic-induced endothelial dysfunction, possibly due to the antioxidant effect of ALA.
# 2004 Elsevier Ireland Ltd. All rights reserved.
Keywords: a-Lipoic acid; Oxidative stress; Endothelial dysfunction; Hypertriglyceridemia; Diabetes mellitus
Department
Dept. of Physiology (생리학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Keun-Gyu Park et al. (2004). Prevention and treatment of macroangiopathy:
focusing on oxidative stress. Diabetes Research and Clinical Practice, 66(Supplement), S57–S62. doi: 10.1016/j.diabres.2003.08.017
Type
Article
ISSN
0168-8227
DOI
10.1016/j.diabres.2003.08.017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35582
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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