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Incidence of Propofol Injection Pain and Effect of Lidocaine Pretreatment During Upper Gastrointestinal Endoscopy

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Author(s)
Ji Suk KwonEun Soo KimKwang Bum ChoKyung Sik ParkWoo Young ParkJeong Eun LeeTae Yol KimByoung Kuk JangWoo Jin ChungJae Seok Hwang
Keimyung Author(s)
Kim, Eun SooCho, Kwang BumPark, Kyung SikPark, Woo YoungJang, Byoung KukChung, Woo JinHwang, Jae Seok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Digestive Diseases and Sciences
Issued Date
2012
Volume
57
Issue
5
Abstract
Background/Aims Propofol has been used in the past for
sedation in upper gastrointestinal (GI) endoscopic procedures.
This study aimed to measure the incidence of propofol
injection pain and evaluate the effect of lidocaine on
pain caused during sedative upper GI endoscopic
examinations.
Methods Subjects scheduled to undergo sedative diagnostic
upper GI endoscopy were randomly assigned to
lidocaine and placebo groups. Pretreatment with a bolus of
1% lidocaine 2 ml or normal saline 2 ml into the largest
dorsal vein of the non-dominant hand was followed by
propofol administration. Pain intensity was estimated by an
examiner blinded to the group assignment using a fourpoint
verbal rating scale. A score of 1–3 was regarded as
pain.
Results A total of 121 patients (males, 69; age,
58.6 ± 12.1 years) completed the study; 61 and 60 subjects
were randomly assigned to the lidocaine and placebo
groups, respectively. The incidence of pain during upper
GI endoscopy was 60%. The lidocaine group showed a
lower incidence of pain than the placebo group (37.7% vs.
60.0%, P = 0.018). The lidocaine group perceived significantly
less pain than the placebo group (median pain
score, 0 vs. 1, P = 0.008). Only lidocaine pretreatment was
an independently associated factor against pain perception
(OR, 0.380; 95% CI, 0.177–0.815; P = 0.013).
Conclusions Pretreatment using lidocaine was found to
be effective in reducing propofol injection-induced pain.
However, its usefulness for GI endoscopic procedures in
daily clinical practice needs further evaluation because of
the low intensity of pain.
Keywords Propofol Pain Lidocaine Endoscopy
Keimyung Author(s)(Kor)
김은수
조광범
박경식
박우영
장병국
정우진
황재석
Publisher
School of Medicine
Citation
Ji Suk Kwon et al. (2012). Incidence of Propofol Injection Pain and Effect of Lidocaine
Pretreatment During Upper Gastrointestinal Endoscopy. Digestive Diseases and Sciences, 57(5), 1291–1297. doi: 10.1007/s10620-011-1992-4
Type
Article
ISSN
0163-2116
Source
https://link.springer.com/article/10.1007%2Fs10620-012-2158-8
DOI
10.1007/s10620-011-1992-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35593
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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