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Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

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Author(s)
Jae Jun ParkJae Hee CheonBo Young KimDuk Hwan KimEun Soo KimTae Il KimKyoung Ryul LeeWon Ho Kim
Keimyung Author(s)
Kim, Eun Soo
Department
Dept. of Internal Medicine (내과학)
Journal Title
Digestive Diseases and Sciences
Issued Date
2009
Volume
54
Issue
7
Abstract
Although triggering receptor expressed on
myeloid cells-1 (TREM-1) has recently been shown to be
upregulated in the intestines of patients with inflammatory
bowel disease (IBD), it remains unclear whether serumsolubleTREM-
1 (sTREM-1) level reflects disease activity in
patients with IBD. This study aimed to evaluate the correlation
of sTREM-1 level with disease activity in IBD. We
prospectively enrolled consecutive patients with IBD and
assessed their clinical disease activity using the guidelines of
the American College of Gastroenterology. At the time that
disease activity was assessed, sTREM-1 level (using an
enzyme-linked immunosorbent assay method) and other
laboratory findings including erythrocyte sedimentation rate
(ESR) and C-reactive protein (CRP) were also measured. A
total of 31 patients with ulcerative colitis (UC) and 22 with
Crohn’s disease (CD) were enrolled. The mean sTREM-1
level in patients with either UC (60.4 ± 41.8 pg/ml) or CD
(66.5 ± 42.4 pg/ml) was significantly higher than in healthy
controls (0.6 ± 1.4 pg/ml) (P = 0.003 and P = 0.002,
respectively). In patients with UC, sTREM-1 level was more
highly correlated with disease activity (r = 0.849) than was
ESR (r = 0.619) or CRP level(r = 0.546). Moreover,
sTREM-1 level correlated well with disease activity irrespective
of disease extent. In patients with CD, sTREM-1
level was lower in those with remission compared with those
without (46.8 ± 35.3 pg/ml versus 77.8 ± 43.1 pg/ml), but
this trend did not reach statistical significance (P = 0.100).
The results of our study suggest that sTREM-1 could be a
potential marker for disease activity in IBD patients, especially
those with UC.
Keywords Triggering receptor expressed on myeloid
cells-1 Ulcerative colitis Crohn’s disease Disease
activity
Keimyung Author(s)(Kor)
김은수
Publisher
School of Medicine
Citation
Jae Jun Park et al. (2009). Correlation of Serum-Soluble Triggering Receptor Expressed
on Myeloid Cells-1 with Clinical Disease Activity
in Inflammatory Bowel Disease. Digestive Diseases and Sciences, 54(7), 1525–1531. doi: 10.1007/s10620-008-0514-5
Type
Article
ISSN
0163-2116
Source
https://link.springer.com/article/10.1007%2Fs10620-008-0514-5
DOI
10.1007/s10620-008-0514-5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35599
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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