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Matrix Metalloproteinase (MMP)-3 Polymorphism in Patients with HBV Related Chronic Liver Disease

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Author(s)
Hyun Phil ShinJoung Il LeeJoo-Ho JungSung-Vin YimHyun Jeong KimJae Myung ChaJong Beom ParkKwang Ro JooJae Seok HwangByoung-Kuk Jang
Keimyung Author(s)
Hwang, Jae SeokJang, Byoung Kuk
Department
Dept. of Internal Medicine (내과학)
Institute for Medical Science (의과학연구소)
Journal Title
Digestive Diseases and Sciences
Issued Date
2008
Volume
53
Issue
3
Abstract
A common and important problem in patients with chronic hepatitis B is the progression of liver fibrosis. Matrix metalloproteinases (MMPs) play an important role in the progression of liver fibrosis. Our aim of this study was to examine the association of MMP-3 polymorphism with liver cirrhosis in Korean patients with chronic hepatitis B. Genomic DNA was extracted from 127 patients with chronic hepatitis B (CHB), 92 patients with hepatitis B virus (HBV)-related liver cirrhosis (HBV-LC), and 146 healthy subjects. MMP-3 polymorphism was determined by polymerase-chain reaction-based assays, and the association with the progression of liver cirrhosis was investigated. With regard to MMP-3 polymorphism, there was no statistical difference in genotype distributions among the three groups. However, the peripheral platelet count of the 5A carriers was significantly lower than that of the 6A homozygotes in the HBV-LV group (85.0 ± 36.9 vs. 109.8 ± 47.0 × 109/l; P = 0.02). With MMP-3 promoter polymorphism (rs3025058), a lower peripheral blood platelet count, which was related to advanced liver cirrhosis, was observed in 5A carriers. Therefore, more studies of MMP-3 gene polymorphism with larger populations should be conducted to further understand its role in the progression of liver cirrhosis.


Keywords
Chronic hepatitis B – Liver fibrosis – Matrix metalloproteinases – MMP-3
Keimyung Author(s)(Kor)
황재석
장병국
Publisher
School of Medicine
Citation
Hyun Phil Shin et al. (2008). Matrix Metalloproteinase (MMP)-3 Polymorphism in Patients with HBV Related Chronic Liver Disease. Digestive Diseases and Sciences, 53(3), 823–829. doi: 10.1007/s10620-007-9937-7
Type
Article
ISSN
0163-2116
Source
https://link.springer.com/article/10.1007%2Fs10620-007-9937-7
DOI
10.1007/s10620-007-9937-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35601
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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