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The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis

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Author(s)
Jin Ha LeeJae Hee CheonEun Soo KimMoon Jae ChungWonseok KangDuk Hwan KimYou Jung HaJae Jun ParkTae Il KimWon Ho Kim
Keimyung Author(s)
Kim, Eun Soo
Department
Dept. of Internal Medicine (내과학)
Journal Title
Digestive Diseases and Sciences
Issued Date
2010
Volume
55
Issue
5
Abstract
Perinuclear anti-neutrophil cytoplasmic antibody
(pANCA) is a serological marker associated with
various immune-mediated diseases whose clinical significance
and possible diagnostic roles in ulcerative colitis (UC)
are still unclear. We aimed to evaluate the prevalence of
pANCA expression and its association with clinical findings
and disease course in Korean patients with UC. This study
included 484 patients with UC who were diagnosed and
treated between 1990 and 2006 at Severance Hospital,
Yonsei University, Seoul, Korea, and were followed for at
least 1 year. Clinical findings at diagnosis, disease extent,
treatment modalities used, and cumulative relapse rates were
analyzed and compared to pANCA expression. Of the 484
patients, 405 (83.7%) were evaluated for pANCA and were
eligible for analysis. The overall pANCA prevalence was
22.1%, with a female preponderance (male, 21.5%; female,
31.6%; P\0.05). Proctitis was more common in pANCAnegative
patients (pANCA-negative, 37.6%; pANCA-positive,
25.2%, P\0.05). UC activity index and cumulative
relapse rates were higher in pANCA-positive patients.
However, there were no significant differences in the
cumulative probability of steroid and immunosuppressant
use and operation rate between the two groups. The prevalence
of pANCA expression in Korean patients with UC was
relatively low compared to that in Western countries.
Although UC patients with pANCA expression had more
severe clinical findings at diagnosis and higher cumulative
relapse rates in our study, further prospective studies are
warranted to clarify whether pANCA positivity influences
the initial clinical presentation or disease aggressiveness.
Keywords Disease activity Korean pANCA
Prevalence Ulcerative colitis
Keimyung Author(s)(Kor)
김은수
Publisher
School of Medicine
Citation
Jin Ha Lee et al. (2010). The Prevalence and Clinical Significance of Perinuclear
Anti-neutrophil Cytoplasmic Antibody in Korean Patients
with Ulcerative Colitis. Digestive Diseases and Sciences, 55(5), 1406–1412. doi: 10.1007/s10620-009-0847-8
Type
Article
ISSN
0163-2116
Source
https://link.springer.com/article/10.1007%2Fs10620-009-0847-8
DOI
10.1007/s10620-009-0847-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35603
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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