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Increased power spectral density in resting-state pain-related brain networks in fibromyalgia

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Author(s)
Ji-Young KimSeong-Ho KimJeehye SeoSang-Hyon KimSeung Woo HanEon Jeong NamSeong-Kyu KimHui Joong LeeSeung-Jae LeeYang-Tae KimYongmin Chang
Keimyung Author(s)
Kim, Sang HyonKim, Yang Tae
Department
Dept. of Internal Medicine (내과학)
Dept. of Psychiatry (정신건강의학)
Journal Title
Pain
Issued Date
2013
Volume
154
Issue
9
Abstract
Fibromyalgia (FM), characterized by chronic widespread pain, is known to be associated with heightened
responses to painful stimuli and atypical resting-state functional connectivity among pain-related
regions of the brain. Previous studies of FM using resting-state functional magnetic resonance imaging
(rs-fMRI) have focused on intrinsic functional connectivity, which maps the spatial distribution of temporal
correlations among spontaneous low-frequency fluctuation in functional MRI (fMRI) resting-state
data. In the current study, using rs-fMRI data in the frequency domain, we investigated the possible alteration
of power spectral density (PSD) of low-frequency fluctuation in brain regions associated with central
pain processing in patients with FM. rsfMRI data were obtained from 19 patients with FM and 20 agematched
healthy female control subjects. For each subject, the PSDs for each brain region identified from
functional connectivity maps were computed for the frequency band of 0.01 to 0.25 Hz. For each group,
the average PSD was determined for each brain region and a 2-sample t test was performed to determine
the difference in power between the 2 groups. According to the results, patients with FM exhibited significantly
increased frequency power in the primary somatosensory cortex (S1), supplementary motor
area (SMA), dorsolateral prefrontal cortex, and amygdala. In patients with FM, the increase in PSD did
not show an association with depression or anxiety. Therefore, our findings of atypical increased frequency
power during the resting state in pain-related brain regions may implicate the enhanced resting-
state baseline neural activity in several brain regions associated with pain processing in FM.
Keimyung Author(s)(Kor)
김상현
김양태
Publisher
School of Medicine
Citation
Ji-Young Kim et al. (2013). Increased power spectral density in resting-state pain-related brain
networks in fibromyalgia. Pain, 154(9), 1792–1797. doi: 10.1016/j.pain.2013.05.040
Type
Article
ISSN
0304-3959
Source
http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=23714266
DOI
10.1016/j.pain.2013.05.040
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35619
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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