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BRAF and RAS Mutations in Follicular Variants of Papillary Thyroid Carcinoma

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Author(s)
Ji Young ParkWook Youn KimTae Sook HwangSang Sook LeeHyunkyung KimHye Seung HanSo Dug LimWan Seop KimYoung Bum YooKyoung Sik Park
Keimyung Author(s)
Lee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Endocrine Pathology
Issued Date
2013
Volume
24
Issue
2
Abstract
Follicular variants of papillary thyroid carcinoma
(FVPTC), particularly the encapsulated subtype, often cause
a diagnostic dilemma. Therefore, many FVPTCs are
interpreted as “indeterminate” in preoperative fine-needle
aspiration (FNA). The aim of this study was to analyze the
genotypic changes in BRAF codons 600 and 601, as well as
the N, H, and KRAS codons 12, 13, and 61 in FVPTCs and
investigate the usefulness of preoperative BRAF and RAS
mutation analysis as an adjunct diagnostic tool along with
routine FNA. Surgically resected thyroid nodules were
reviewed to establish the histological diagnosis of FVPTC.
All preoperative FNA diagnoses were categorized according
to the Bethesda Reporting System. Mutations in BRAF codons
600 and 601, and N, H, KRAS codons 12, 13, and 61
were analyzed by pyrosequencing. Of 132 cases, 81
(61.4 %) had a point mutation in one of the BRAF V600E,
BRAF K601E, or RAS oncogenes; BRAF V600E in
43(32.6 %), BRAF K601E in three (2.3 %), and RAS in 35
(26.5 %) cases. All mutations were mutually exclusive. Of
78 cases with an FNA indeterminate category diagnosis, 51
(65.4 %) were positive for mutations: 24 for BRAF V600E,
3 for BRAF K601E, and 24 for the RAS gene. The KRAS
mutation was more frequently found than the HRAS mutation,
comprising 22.9 % of the RAS mutations, and all KRAS
mutations were located at codon 61. This study demonstrated
that either BRAF or RAS mutations were present in two
thirds of FVPTCs and these mutations were mutually
exclusive.
Keywords BRAF . RAS . Follicular variant . Papillary
thyroid carcinoma
Keimyung Author(s)(Kor)
이상숙
Publisher
School of Medicine
Citation
Ji Young Park et al. (2013). BRAF and RAS Mutations in Follicular Variants of Papillary
Thyroid Carcinoma. Endocrine Pathology, 24(2), 69–76. doi: 10.1007/s12022-013-9244-0
Type
Article
ISSN
1046-3976
Source
https://link.springer.com/article/10.1007%2Fs12022-013-9244-0
DOI
10.1007/s12022-013-9244-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35621
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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