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The Effects on Cognitive Function and Behavioral Problems of Topiramate Compared to Carbamazepine as Monotherapy for Children with Benign Rolandic Epilepsy

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Author(s)
Hoon-Chul KangBaik-Lin EunChang Wu LeeHan Ku MoonJoon-Sik KimDong Wook KimJoon Soo LeeKyu Young ChaeByung Ho ChaEun Sook SuhJung Chae ParkKyunghwa LimEun Hye HaDong Ho SongHeung Dong KimKorean Pediatric Topiramate Study Group
Keimyung Author(s)
Kim, Joon Sik
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Epilepsy
Issued Date
2007
Volume
48
Issue
9
Abstract
Summary: Purpose: To evaluate the cognitive and behavioral
effects of topiramate (TPM) versus carbamazepine (CBZ) using
efficacious doses of each drug as monotherapy for children with
benign rolandic epilepsy.
Methods: A multicenter, randomized, open-label, observer-
blinded, parallel-group clinical trial was conducted. TPM was
introduced at a dose of 12.5 mg/day with the minimum target
dose of 50 mg/day in patients <30 kg and 75 mg/day in pa-
tients >30 kg over 4 weeks. CBZ was started at a dose of 10
mg/kg/day with the minimum target dose of 20 mg/kg/day over
4 weeks. Additional individual escalation was allowed up to a
maximum target dose. The primary study end point was change
on a neuropsychological test battery after 28 weeks of treatment.
Results: Neuropsychological data were available for 88 pa-
tients (45 patients for TPM and 43 patients for CBZ). Of the cog-
nitive variables measured, arithmetic showed significant worsen-
ing in TPM (p = 0.037). An additional test, for maze, also showed
a significantly greater improvement for CBZ (p = 0.026). Of be-
havioral variables, no significant changes were found but the
scores had a negative trend for the TPM. When 30 patients
on the minimum target dose for TPM were compared to 40
patients treated with minimum target CBZ, there was no sig-
nificant worsening of cognitive and behavioral effects in the
TPM.
Conclusion: The pattern of neuropsychometric changes with
TPM seemed to be slightly worse overall than CBZ. How-
ever, outcome with the minimum target dose did not differ
significantly in comparisons between the treatment groups.
Key Words: Cognitive function—Behavioral problems—
Topiramate—Carbamazepine—Benign rolandic epilepsy.
Keimyung Author(s)(Kor)
김준식
Publisher
School of Medicine
Citation
Hoon-Chul Kang et al. (2007). The Effects on Cognitive Function and Behavioral Problems
of Topiramate Compared to Carbamazepine as Monotherapy
for Children with Benign Rolandic Epilepsy. Epilepsy, 48(9), 1716–1723. doi: 10.1111/j.1528-1167.2007.01160.x
Type
Article
ISSN
0013-9580
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1528-1167.2007.01160.x
DOI
10.1111/j.1528-1167.2007.01160.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35638
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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