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Validation of the Generalized Anxiety Disorder-7 in people with epilepsy: A MEPSY study

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Author(s)
Jong-Geun SeoYong Won ChoSe-Jin LeeJang-Joon LeeJi-Eun KimHye-Jin MoonSung-Pa Park
Keimyung Author(s)
Cho, Yong WonMoon, Hye Jin
Department
Dept. of Neurology (신경과학)
Journal Title
Epilepsy & Behavior
Issued Date
2014
Volume
35
Abstract
The Generalized Anxiety Disorder-7 (GAD-7) is a valuable instrument to screen for anxiety in primary care patients.
However, it has not been validated in people with epilepsy (PWE). Therefore, we validated the GAD-7
and examined its differential effect fromadverse effects of antiepileptic drugs (AEDs) on the detection of anxiety
in Korean PWE. Eligible patients who visited outpatient clinics in 4 tertiary care hospitals and 1 secondary care
hospital underwent several instruments including the Mini International Neuropsychiatric Interview—Plus
Version 5.0.0 (MINI-Plus 5.0.0), the Korean version of the Neurological Disorders Depression Inventory for
Epilepsy (K-NDDI-E), the Korean version of the Liverpool Adverse Event Profile (K-LAEP), and the Quality of
Life in Epilepsy-10 (QOLIE-10). Two hundred forty-three patients were enrolled in the study, and 51 (21.0%) patients
had GAD by theMINI-Plus 5.0.0. Cronbach's α coefficient for the GAD-7was 0.924. At a cutoff score of 6, the
GAD-7 had a sensitivity of 92.2%, a specificity of 89.1%, a positive predictive value of 69.1%, and a negative predictive
value of 97.7%. The GAD-7 score was well correlated with the K-NDDI-E score, the K-LAEP score, and the
QOLIE-10 overall and subscale scores. The impact of adverse effects of AEDs on the GAD-7 was less than that
on the K-NDDI-E. In conclusion, the GAD-7 is a reliable and valid screening tool for detecting GAD in PWE.
Keimyung Author(s)(Kor)
조용원
문혜진
Publisher
School of Medicine
Citation
Jong-Geun Seo et al. (2014). Validation of the Generalized Anxiety Disorder-7 in people with epilepsy:
A MEPSY study. Epilepsy & Behavior, 35, 59–63. doi: 10.1016/j.yebeh.2014.04.005
Type
Article
ISSN
1525-5050
Source
https://www.sciencedirect.com/science/article/pii/S1525505014001267?via%3Dihub
DOI
10.1016/j.yebeh.2014.04.005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35644
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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