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Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy

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Author(s)
Young-Min LimYong-Won ChoSadat ShamimJeffrey SolomonRasmus BirnWen Ming LuhWilliam D. GaillardEva K. RitzlWilliam H. Theodore
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Epilepsy Research
Issued Date
2008
Volume
82
Issue
2-3
Abstract
Summary
Purpose: Arterial spin labeling (ASL) is a developing magnetic resonance imaging (MRI) method
for noninvasive measurement of cerebral blood flow (CBF). The purpose of this study was to
evaluate the usefulness of ASL for detecting interictal temporal hypoperfusion in temporal lobe
epilepsy (TLE). ASL-derived CBF measurements were compared with those derived from H2
15O
positron emission tomography (PET).
Methods: 11 normal controls and 10 patients with medically intractable TLE were studied.
Pulsed ASL (PASL) with quantitative imaging of perfusion using a single subtraction, second version
(QUIPSS II) was performed in all subjects and H2
15O PET was performed in patients. Regional
CBF values in the mesial and lateral temporal lobes were measured utilizing quantitative analysis
of perfusion images. A perfusion asymmetry index (AI) was calculated for each region.
Results: In patients, mean CBF in the mesial temporal lobe was not significantly different
between PASL and H2
15O PET, and ipsilateral mesial temporal CBF was lower than contralateral
CBF with both techniques. PASL detected significant mesial temporal perfusion asymmetry
agreeing with EEG laterality in four patients. H2
15O PET found ipsilateral interictal hypoperfusion
in three. Both scans found unilateral hypoperfusion in one patient with bilateral EEG
discharges.
Conclusions: Pulsed ASL may be a promising approach to detecting interictal hypoperfusion in
TLE. This method has potential as a clinical alternative to H2
15O PET due to noninvasiveness
and easy accessibility.
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine
Citation
Young-Min Lim et al. (2008). Usefulness of pulsed arterial spin labeling MR
imaging in mesial temporal lobe epilepsy. Epilepsy Research, 82(2–3), 183–189. doi: 10.1016/j.eplepsyres.2008.08.001
Type
Article
ISSN
0920-1211
DOI
10.1016/j.eplepsyres.2008.08.001
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35646
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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