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Metabolic parameters using 18F-FDG PET/CT correlate with occult lymph node metastasis in squamous cell lung carcinoma

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Author(s)
Do-Hoon KimBong-Il SongChae Moon HongShin Young JeongSang-Woo LeeJaetae LeeByeong-Cheol Ahn
Keimyung Author(s)
Song, Bong Il
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
European Journal of Nuclear Medicine and Molecular Imaging
Issued Date
2014
Volume
41
Issue
11
Abstract
Purpose The aim of this study was to investigate predictability
of occult lymph node metastasis (OLM) using metabolic
parameters on pretreatment 18F-fluoro-2-deoxy-D-glucose
(FDG) positron emission tomography (PET)/CT in squamous
cell non-small cell lung carcinoma (SC-NSCLC) patients who
were clinically node negative (cN0) before surgery.
Methods A total of 63 cN0 SC-NSCLC patients (M/F = 61/2,
mean age 64.1±8.0) who underwent curative surgery with
lymph node dissection were enrolled in this study. Metabolic
tumor volume (MTV) of the primary tumor was obtained with
a standardized uptake value (SUV) threshold of 2.5. Total
lesion glycolysis (TLG) was calculated by multiplication of
the MTV and its SUVmean. Metabolic parameters (SUVmax,
MTV, and TLG) and clinicopathological factors were analyzed
for OLM.
Results Of 63 patients, 12 (19.0 %) had OLM. Significantly
higher SUVmax,MTV, TLG, and pathological tumor size were
observed in patients with OLM. The optimal cutoff values for
prediction of OLM determined using a receiver-operating
characteristic (ROC) curve were 8.8 for SUVmax, 18.9 cm3
for MTV, 88.4 for TLG, and 2.8 cm for pathological tumor
size. Univariate analysis showed correlation of SUVmax,
MTV, and TLG with the rate of OLM. In multivariate analyses,
high SUVmax and MTV showed an association with an
increased risk of OLM, after adjusting for age, sex, pathological
tumor size, T stage, and location.
Conclusion Metabolic parameters on pretreatment 18F-FDG
PET/CT were significant predictors for OLM in cN0 SCNSCLC
patients. Surgical planning can be tailored based on
the parameters in order to reduce the risk of hidden residual
lymph node metastases in patients.
Keywords Squamous cell lung carcinoma . Prediction .
Occult lymph nodemetastasis . 18F-FDGPET/CT . Metabolic
parameter
Keimyung Author(s)(Kor)
송봉일
Publisher
School of Medicine
Citation
Do-Hoon Kim et al. (2014). Metabolic parameters using 18F-FDG PET/CT correlate
with occult lymph node metastasis in squamous cell
lung carcinoma. European Journal of Nuclear Medicine and Molecular Imaging, 41(11), 2051–2057. doi: 10.1007/s00259-014-2831-6
Type
Article
ISSN
1619-7070
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs00259-014-2831-6
DOI
10.1007/s00259-014-2831-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35656
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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