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Bone marrow immunoscintigraphy using technetium-99m anti-granulocyte antibody in multiple myeloma

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Author(s)
Sang-Kyun SohnByeong-Cheol AhnSang-Woo LeeDong-Hwan KimKyung-Ah ChunJung-Gyun KimSo-Hyang ParkHong-Suk SongKyu Bo LeeJaetae Lee
Keimyung Author(s)
Song, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
European Journal of Nuclear Medicine and Molecular Imaging
Issued Date
2002
Volume
29
Issue
5
Abstract
. Conventional skeletal radiography and bone
scan have certain limitations in the initial evaluation of
bone and bone marrow lesions in multiple myeloma
(MM). In this study we investigated the value of bone
marrow immunoscintigraphy (BMIS) using anti-granulocyte
monoclonal antibody (AGA) for the diagnosis of
bone involvement of MM, in comparison with bone scan
and skeletal radiography. Whole-body BMIS using technetium-
99m-labelled AGA was performed in 22 MM patients
(15 male, 7 female) and the imaging findings compared
with those of skeletal radiography and 99mTc-methylene
diphosphonate bone scan. The findings of bone
marrow aspiration and serum biochemical findings were
also compared with BMIS findings. Abnormal findings
of BMIS were defined as presence of a focal photon defect
in the axial skeleton or expansion of peripheral bone
marrow. A total of 124 focal lesions were detected in
19 subjects (86%) by skeletal radiography, bone scan or
BMIS. BMIS detected 92 lesions (74%) in 19 subjects,
whereas skeletal radiography detected 58 focal lesions
(47%) in 14 and bone scan 40 lesions (32%) in 11. Fiftyone
(41%) of the 124 lesions were only seen on BMIS.
Spine and pelvic lesions were better visualised by BMIS,
whereas skull lesions were better seen with skeletal radiography,
and bone scan detected more lesions in the ribs.
Marrow expansion was noted in 15 subjects (68%) on
BMIS, and its grade correlated with marrow cellularity
and myeloma cell percentage in bone marrow aspirates
(P=0.0055 and P=0.0541, respectively). BMIS revealed
abnormal lesions in one of three stage II patients and
17 out of 19 stage III patients. The number of lesions of
the thoracolumbar vertebrae on BMIS was correlated
with cellularity (P=0.0393), but not with myeloma cell
percentage (P=0.1262). These findings suggest that the
results of BMIS with 99mTc-labelled AGA correlate with
clinical stage, and thus reflect the functional status of
bone marrow in MM patients. BMIS might be useful for
the detection of bone involvement of MM when skeletal
radiography or bone scan is inconclusive, especially for
vertebral lesions.
Keywords: Multiple myeloma – Bone marrow – Bone
scan – Immunoscintigraphy – Skeletal radiography
Keimyung Author(s)(Kor)
송홍석
Publisher
School of Medicine
Citation
Sang-Kyun Sohn et al. (2002). Bone marrow immunoscintigraphy using technetium-99m
anti-granulocyte antibody in multiple myeloma. European Journal of Nuclear Medicine and Molecular Imaging, 29(5), 591–596. doi: 10.1007/s00259-001-0747-4
Type
Article
ISSN
0340-6997
DOI
10.1007/s00259-001-0747-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35657
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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