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Effects of (−)-epigallocatechin-3-gallate on pancreatic beta-cell damage in streptozotocin-induced diabetic rats

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Author(s)
Seung-Young YunSang-Pyo KimDae-Kyu Song
Keimyung Author(s)
Song, Dae KyuKim, Sang Pyo
Department
Dept. of Physiology (생리학)
Dept. of Pathology (병리학)
Journal Title
European Journal of Pharmacology
Issued Date
2006
Volume
541
Issue
1-2
Abstract
Oxygen free radicals, which are produced as a result of chronic hyperglycemia, are implicated in many diabetic complications. (−)-
Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, has been shown to have both antioxidant and pro-oxidant activities, but its effect on
oxidative stress of pancreatic beta cells in vivo is unclear. Here we evaluated the effects of nanomolar concentrations of EGCG on beta-cell
survival and the response to high glucose loading in streptozotocin-induced diabetic rats. A 4-day intraperitoneal treatment with EGCG (5 mg/kg/
day) further impaired the beta-cell response to high glucose in the diabetic rats. EGCG exacerbated the loss of islet cell mass and insulinimmunoreactivity
in beta cells. These results suggest that, even at nanomolar plasma concentrations, EGCG acts as a pro-oxidant rather than an
antioxidant, at least in beta cells in vivo.
© 2006 Elsevier B.V. All rights reserved.
Keywords: (−)-Epigallocatechin-3-gallate; Oxygen free radical; Streptozotocin; Glucose; Insulin
Keimyung Author(s)(Kor)
송대규
김상표
Publisher
School of Medicine
Citation
Seung-Young Yun et al. (2006). Effects of (−)-epigallocatechin-3-gallate on pancreatic beta-cell
damage in streptozotocin-induced diabetic rats. European Journal of Pharmacology, 541(1–2), 115–121. doi: 10.1016/j.ejphar.2006.04.040
Type
Article
ISSN
0014-2999
Source
https://www.sciencedirect.com/science/article/pii/S0014299906004250?via%3Dihub
DOI
10.1016/j.ejphar.2006.04.040
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35661
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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