Lymphadenectomy increases the prognostic value of the revised 2009 FIGO staging system for endometrial cancer: A multi-center study

Abstract

Background: We investigated whether pelvic or para-aortic lymphadenectomy increases the prognostic value of the revised 2009 FIGO staging system in patients with endometrial cancer (EC). Methods: We reviewed 786 patients with EC from six tertiary medical centers between July 1996 and June 2008. All patients were classified according to the 1988 FIGO staging system: IA (n ¼ 234); IB (n ¼ 270); IC (n ¼ 109); IIA (n ¼ 35); IIB (n ¼ 29); IIIA (n ¼ 37); IIIB (n ¼ 3); IIIC (n ¼ 69), and the revised 2009 FIGO staging system was also applied to divide them: IA (¼542); IB (¼125); II (n ¼ 29); IIIA (n ¼ 18); IIIB (n ¼ 3); IIIC1 (n ¼ 43); IIIC2 (n ¼ 26). Prognostic values between the 1988 and the revised 2009 FIGO staging systems were compared by multivariate Cox’s proportional hazard analysis. Results: The 1988 FIGO stage IC, IIB, IIIA þ IIIB and IIIC, and the revised 2009 FIGO stage IB, II, IIIA þ IIIB and IIIC2 diseases were prognostic factors for poor PFS, whereas the 1988 FIGO stage IIB and IIIC, and the revised 2009 FIGO stage II, IIIA þ IIIB and IIIC2 diseases were unfavorable prognostic factors for OS. Although these results were similar to those in 595 patients who underwent pelvic or para-aortic lymphadenectomy, the revised 2009 FIGO stage IIIC1 disease was an additional prognostic factor for poor PFS and OS (adjusted HRs, 4.19 and 11.25; 95% CIs, 1.39e12.60 and 2.23e36.74). Conclusions: The revised 2009 FIGO staging system had a higher prognostic value than the 1988 FIGO staging system, and pelvic or paraaortic lymphadenectomy increased the prognostic value of the revised 2009 FIGO staging system for EC. 2011 Elsevier Ltd. All rights reserved. Keywords: Lymphadenectomy; The revised 2009 FIGO staging system; Endometrial cancer Introduction Endometrial cancer (EC) is the seventh most common malignancy in