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Changing etiology of community-acquired bacterial meningitis in adults: a nationwide multicenter study in Korea

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Author(s)
S.-Y. MoonD. R. ChungS.-W. KimH. H. ChangH. LeeD. S. JungY.-S. KimS. I. JungS. Y. RyuS. T. HeoC. MoonH. K. KiJ. S. SonK. T. KwonS. Y. ShinJ. S. LeeS. S. LeeJ.-Y. RheeJ.-A. LeeM. K. JoungH. S. CheongK. R. PeckJ.-H. Song
Keimyung Author(s)
Ryu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
European Journal of Clinical Microbiology and Infectious Diseases
Issued Date
2010
Volume
29
Issue
7
Abstract
Epidemiologic data on the etiologic organisms is important for appropriate empirical antibiotic treatment of bacterial meningitis. We identified the etiologies of community-acquired bacterial meningitis in Korean adults and the associated epidemiological factors. A retrospective, multicenter nationwide study was carried out. Patients 18 years of age or older with community-acquired bacterial meningitis with a confirmed pathogen were enrolled. Demographic, clinical, and microbiological data were collected. One hundred and ninety-five cases were collected. Streptococcus pneumoniae was the most common pathogen (50.8%), followed by Staphylococcus aureus (10.3%), Klebsiella pneumoniae (7.7%), Listeria monocytogenes (6.7%), and group B Streptococcus (3.1%). The penicillin resistance rate of the S. pneumoniae was 60.3%; 40.0% of the organisms were not susceptible to third-generation cephalosporins. The combination of third-generation cephalosporin with vancomycin was used in 76.3% of cases. Steroids were given before or with the first dose of antibiotics in 37.4% of patients. The 30-day mortality rate was 20.5% and neurological sequelae developed in 15.6% of cases. S. pneumoniae was the most common organism identified in community-acquired bacterial meningitis among Korean adults. S. aureus, K. pneumoniae, L. monocytogenes, and group B Streptococcus were also common. S. pneumoniae had high rates of resistance to penicillin and third-generation cephalosporins.
Keimyung Author(s)(Kor)
류성열
Publisher
School of Medicine
Citation
S.-Y. Moon et al. (2010). Changing etiology of community-acquired bacterial
meningitis in adults: a nationwide multicenter study in Korea. European Journal of Clinical Microbiology and Infectious Diseases, 29(7), 793–800. doi: 10.1007/s10096-010-0929-8
Type
Article
ISSN
0934-9723
Source
https://link.springer.com/article/10.1007%2Fs10096-010-0929-8
DOI
10.1007/s10096-010-0929-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35672
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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