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Incidental pituitary uptake on whole-body 18F-FDG PET/CT: a multicentre study

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Author(s)
Shin Young JeongSang-Woo LeeHui Joong LeeSungmin KangJi-Hyoung SeoKyung Ah ChunIhn Ho ChoKyung Sook WonSeok Kil ZeonByeong-Cheol AhnJaetae Lee
Keimyung Author(s)
Won, Kyoung SookZeon, Seok Kil
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
European Journal of Nuclear Medicine and Molecular Imaging
Issued Date
2010
Volume
37
Issue
12
Abstract
Purpose The purpose of this study was to determine the
incidence of incidental pituitary uptake on whole-body 18Ffluorodeoxyglucose
(FDG) positron emission tomography/
computed tomography (PET/CT) and to investigate its
clinical significance.
Methods The files of 40,967 patients who underwent wholebody
FDG PET/CT were retrospectively reviewed. Quantification
of pituitary metabolic activity was obtained by
using the maximum standardized uptake value (SUVmax).
Hormone assays and pituitary MRIs were performed to
assess pituitary lesions.
Results Focally increased pituitary FDG uptake on PET/CT
was found in 30 of 40,967 patients, accounting for an
incidence of 0.073%. The mean SUVmax of 30 patients was
8.9±6.6 (range: 3.2–32.6). Histological diagnosis was
obtained in three patients and included two growth
hormone-secreting adenomas and one non-functioning
adenoma. Hormone assays were performed on serum
samples from 11 patients, 2 of whom were shown to have
hypersecretion of pituitary hormone. MRI was performed
on 19 patients. Abnormal MRI findings suggesting a
pituitary mass were found in 18 of 19 cases (94.7%). The
mean SUVmax calculated without correction for partial
volume effect for macroadenomas was significantly higher
than the SUVmax for microadenomas (11.5±8.4 vs 4.8±1.3;
p<0.05). There were no cases diagnosed with metastasis to
the pituitary gland during clinical follow-up.
Conclusion Incidental pituitary FDG uptake was a very
rare finding. Cases with incidental pituitary FDG uptake
were diagnosed primarily with clinically non-functioning
adenomas, and there were also a few functioning adenomas.
Further evaluations, including hormone assays and pituitary
MRI, are warranted when pituitary uptake is found on FDG
PET/CT.
Keimyung Author(s)(Kor)
원경숙
전석길
Publisher
School of Medicine
Citation
Shin Young Jeong et al. (2010). Incidental pituitary uptake on whole-body 18F-FDG PET/CT:
a multicentre study. European Journal of Nuclear Medicine and Molecular Imaging, 37(12), 2334–2343. doi: 10.1007/s00259-010-1571-5
Type
Article
ISSN
1619-7070
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs00259-010-1571-5
DOI
10.1007/s00259-010-1571-5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35679
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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