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Hepatoprotective Activity of Licorice Water Extract against Cadmium-induced Toxicity in Rats

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Author(s)
Jong Rok LeeSook Jahr ParkHyeung-Sik LeeSeon Young JeeJungcheol SeoYoung Kyu KwonTaeg Kyu KwonSang Chan Kim
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Evidence - Based Complementary and Alternative Medicine
Issued Date
2009
Volume
6
Issue
2
Abstract
Licorice is commonly used as a cure for digestive disorders and as a detoxification agent in East
Asia. This study investigated the protective effect of licorice water extract against cadmium
(CdCl2, Cd)-induced liver toxicity in rats. To induce acute toxicity, Cd (4 mg/kg body weight)
was dissolved in normal saline and intravenously (i.v.) injected into rats. The rats then received
either a vehicle or licorice water extract (50, 100 mg/kg/day) for 3 days, and were subsequently
exposed to a single injection of Cd 24 h after the last licorice/vehicle treatment. Alanine
aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH)
were significantly increased by Cd treatment. In contrast, pretreatment with licorice reduced
ALT, AST and LDH. In histopathological analysis, licorice decreased the central necrosis
around central veins, the peripheral hemorrhage around portal triads, the percentage of
degenerative hepatic regions (%/mm2 hepatic parenchyma) and the number of degenerative
hepatic cells (N/100 hepatic cells). Licorice also inhibited the increment of Bad (a BH3 domaincontaining
protein) translocation by Cd in liver cells. These results demonstrate that licorice
could have a hepatoprotective effect by inhibiting the translocation of Bad to the mitochondria
in Cd-intoxificated rats.
Keywords: Licorice – Cadmium – Protective Effect – Liver Toxicity – Bad Translocation
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Jong Rok Lee et al. (2009). Hepatoprotective Activity of Licorice Water Extract against
Cadmium-induced Toxicity in Rats. Evidence - Based Complementary and Alternative Medicine, 6(2), 195–201. doi: 10.1093/ecam/nem078
Type
Article
ISSN
1741-427X
DOI
10.1093/ecam/nem078
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35695
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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