계명대학교 의학도서관 Repository

Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review

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Author(s)
Mi-Kyung KimHye-Soon KimIn-Kyu LeeKeun-Gyu Park
Keimyung Author(s)
Kim, Mi KyungKim, Hye Soon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Experimental Diabetes Research
Issued Date
2012
Volume
2012
Abstract
Insulin resistance and pancreatic beta cell dysfunction are major contributors to the pathogenesis of diabetes. Various conditions play a role in the pathogenesis of pancreatic beta cell dysfunction and are correlated with endoplasmic reticulum (ER) stress. Pancreatic beta cells are susceptible to ER stress. Many studies have shown that increased ER stress induces pancreatic beta cell dysfunction and diabetes mellitus using genetic models of ER stress and by various stimuli. There are many reports indicating that ER stress plays an important role in the impairment of insulin biosynthesis, suggesting that reduction of ER stress could be a therapeutic target for diabetes. In this paper, we reviewed the relationship between ER stress and diabetes and how ER stress controls insulin biosynthesis
Keimyung Author(s)(Kor)
김미경
김혜순
Publisher
School of Medicine
Citation
Mi-Kyung Kim et al. (2012). Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review. Experimental Diabetes Research, 2012, 1–7. doi: 10.1155/2012/509437
Type
Article
ISSN
1687-5214
DOI
10.1155/2012/509437
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35700
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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