계명대학교 의학도서관 Repository

Orphan nuclear receptor small heterodimer partner inhibits angiotensin II-stimulated PAI-1 expression in vascular smooth muscle cells

Metadata Downloads
Author(s)
Kyeong-Min LeeHye-Young SeoMi-Kyung KimAe-Kyung MinSeong-Yeol RyuYoon-Nyun KimYoung Joo ParkHueng-Sik ChoiKi-Up LeeWan-Ju ParkKeun-Gyu ParkIn-Kyu Lee
Keimyung Author(s)
Kim, Mi KyungRyu, Seong YeolKim, Yoon NyunPark, Keun Gyu
Department
Dept. of Internal Medicine (내과학)
Institute for Medical Science (의과학연구소)
Journal Title
Experimental and Molecular Medicine.
Issued Date
2010
Volume
42
Issue
1
Abstract
Angiotensin II is a major effector molecule in the development
of cardiovascular disease. In vascular smooth
muscle cells (VSMCs), angiotensin II promotes cellular
proliferation and extracellular matrix accumulation
through the upregulation of plasminogen activator inhibitor-
1 (PAI-1) expression. Previously, we demonstrated
that small heterodimer partner (SHP) represses
PAI-1 expression in the liver through the inhibition of
TGF-β signaling pathways. Here, we investigated
whether SHP inhibited angiotensin II-stimulated PAI-1
expression in VSMCs. Adenovirus-mediated overexpression
of SHP (Ad- SHP) in VSMCs inhibited angiotensin
II- and TGF-β-stimulated PAI-1 expression.
Ad-SHP also inhibited angiotensin II-, TGF-β- and
Smad3-stimulated PAI-1 promoter activity, and angiotensin
II-stimulated AP-1 activity. The level of PAI-1 expression
was significantly higher in VSMCs of SHP-/-
mice than wild type mice. Moreover, loss of SHP increased
PAI-1 mRNA expression after angiotensin II
treatment. These results suggest that SHP inhibits
PAI-1 expression in VSMCs through the suppression
of TGF-β/Smad3 and AP-1 activity. Thus, agents that
target the induction of SHP expression in VSMCs might
help prevent the development and progression of
atherosclerosis.
Keywords: angiotensin II; atherosclerosis; muscle,
smooth, vascular; nuclear receptor subfamily 0, group
B, member 2; plasminogen activator inhibitor 1; transforming
growth factor β
Keimyung Author(s)(Kor)
김미경
류성열
김윤년
박근규
Publisher
School of Medicine
Citation
Kyeong-Min Lee et al. (2010). Orphan nuclear receptor small heterodimer partner inhibits
angiotensin II-stimulated PAI-1 expression in vascular smooth
muscle cells. Experimental and Molecular Medicine., 42(1), 21–29. doi: 10.3858/emm.2010.42.1.002
Type
Article
ISSN
1226-3613
DOI
10.3858/emm.2010.42.1.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35715
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.