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A peroxynitrite decomposition catalyst prevents mechanical allodynia and NMDA receptor activation in the hind-paw ischemia reperfusion injury rats

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Author(s)
KYUNG-HWA KWAKHOON JUNGJUN MO PARKJIN-SEOK YEOHYUNJEE KIMHYUNG CHUL LEESUNG HYE BYUNJONG-CHAN KIMSUNG-SIK PARKDONG GUN LIM
Keimyung Author(s)
Kim, Hyun Jee
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Experimental and Therapeutic Medicine
Issued Date
2014
Volume
7
Issue
2
Abstract
. The contributions of superoxide and nitric oxide to ischemia/reperfusion (I/R)‑induced neuropathic pain have previously been demonstrated in an animal model that mimics the symptoms of complex regional pain syndrome type I (CRPS I). Targeting peroxynitrite, which is the product of their interaction, may provide effective treatments for I/R‑induced neuropathic pain. In this study, the effect of the peroxynitrite decomposition catalyst FeTMPyP [5,10,15,20‑tetrakis (N‑methyl‑4'‑pyridyl)porphyrinato iron (III)], administered at doses of 1, 3 and 10 mg/kg via intraperitoneal injection 30 min prior to reperfusion, was evaluated in rats with chronic post‑ischemic pain. The pain behavior of the rats was tested with a von Frey filament. Phosphorylation of N‑methyl‑D‑aspartate (NMDA) receptors in the L4/6 section of the spinal cord was measured on the third day following reperfusion by western blotting. The rats treated with 3 or 10 mg/kg FeTMPyP demonstrated significant increases in their paw withdrawal thresholds and decreased levels of phosphorylated NMDA receptor subunit 1 compared with those of the vehicle group (all P<0.001). These findings suggest that nitrosative stress, specifically that associated with peroxynitrite, may be involved in the mechanical allodynia and central sensitization that are associated with CRPS I and may provide a rationale for CRPS I treatment strategies using peroxynitrite decomposition catalysts.
Keimyung Author(s)(Kor)
김현지
Publisher
School of Medicine
Citation
KYUNG-HWA KWAK et al. (2014). A peroxynitrite decomposition catalyst prevents mechanical
allodynia and NMDA receptor activation in the hind-paw ischemia reperfusion injury rats. Experimental and Therapeutic Medicine, 7(2), 508–512. doi: 10.3892/etm.2013.1440
Type
Article
ISSN
1792-0981
DOI
10.3892/etm.2013.1440
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35718
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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