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Antiallergic Effects of Vitis amurensis on Mast Cell–Mediated Allergy Model

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Author(s)
Sang-Hyun KimTaeg Kyu KwonTae-Yong Shin
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Institute for Medical Science (의과학연구소)
Journal Title
Experimental Biology and Medicine
Issued Date
2008
Volume
233
Issue
2
Abstract
In this study, we investigated the effect of the methanol extract of fruits of Vitis amurensis Rupr. (Vitaceae; MEVA) on the mast cell–mediated allergy model and studied the possible mechanism of action. Mast cell–mediated allergic disease is involved in many diseases, such as asthma and sinusitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. MEVA inhibited compound 48/80–induced systemic reactions and serum histamine release in a dose-dependent manner in mice. MEVA decreased immunoglobulin E (IgE)–mediated local allergic reactions, passive cutaneous anaphylaxis. MEVA dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. The inhibitory effect of MEVA on histamine release was mediated by the modulation of intracellular calcium. In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)–stimulated secretion of tumor necrosis factor-α, interleukin-6 (IL-6), and IL-8 in human mast cells. The inhibitory effect of MEVA on these proinflammatory cytokines was p38 mitogen-activated protein kinase and nuclear factor-κB (NF-κB) dependent. Our findings provide evidence that MEVA inhibits mast cell–derived, immediate-type allergic reactions and involvement of proinflammatory cytokines, p38 MAPK, and NF-κB in these effects.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Sang-Hyun Kim et al. (2008). Antiallergic Effects of Vitis amurensis on Mast Cell–Mediated Allergy Model. Experimental Biology and Medicine, 233(2), 192–199. doi: 10.3181/0708-RM-222
Type
Article
ISSN
1535-3702
Source
http://journals.sagepub.com/doi/abs/10.3181/0708-RM-222?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.3181/0708-RM-222
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35719
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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