계명대학교 의학도서관 Repository

Clinopodium gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-κB

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Author(s)
Seung-Bin ParkSang-Hyun KimKyoungho SukHyun-Shik LeeTaeg Kyu KwonMin-Gyu JuHoon JeonDae-Keun KimJong-Pil LimTae-Yong Shin
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Experimental Biology and Medicine
Issued Date
2010
Volume
235
Issue
5
Abstract
Mast cell-mediated allergic disease is involved in many diseases such as anaphylaxis, rhinitis, asthma and atopic dermatitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. In this study, we investigated the effect of the water extract of Clinopodium gracile Matsum var. multicaule (WECG) on the mast cell-mediated allergic inflammation and studied the possible mechanism of action. WECG inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated cutaneous anaphylaxis in a dose-dependent manner. WECG dose-dependently reduced histamine release from rat peritoneal mast cells and human mast cells. The inhibitory effect of WECG on histamine release was mediated by the modulation of intracellular calcium. In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-α and interleukin-6 in human mast cells. The inhibitory effect of WECG on these proinflammatory cytokines was nuclear factor-κB (NF-κB) dependent. Our findings provide evidence that WECG inhibits mast cell-derived allergic inflammation and involvement of calcium and NF-κB in these effects
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Seung-Bin Park et al. (2010). Clinopodium gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-κB. Experimental Biology and Medicine, 235(5), 606–613. doi: 10.1258/ebm.2010.009292
Type
Article
ISSN
1535-3702
Source
http://journals.sagepub.com/doi/abs/10.1258/ebm.2010.009292?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1258/ebm.2010.009292
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35720
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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