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Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-κB

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Author(s)
Hui-Hun KimJin-Su YooHyun-Shik LeeTaeg Kyu KwonTae-Yong ShinSang-Hyun Kim
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Experimental Biology and Medicine
Issued Date
2011
Volume
236
Issue
9
Abstract
Mast cell-mediated allergic reaction is involved in many diseases such as asthma and allergic rhinitis. Therefore, discovery of drugs for the prevention or treatment of allergic disease is an important topic in human health. In this study, we evaluated the effects of water extract of Elsholtzia ciliata (Thunb.) Hyland (Labiatae) (WEEC) on mast cell-mediated allergic inflammation and studied the possible mechanisms of action. WEEC inhibited compound 48/80-induced systemic and immunoglobulin E-mediated local anaphylaxis, and serum histamine release in mice. WEEC reduced intracellular calcium levels and downstream histamine release from human mast cells (HMC-1) activated with phorbol 12-myristate 13-acetate and calcium ionophore A23187. In addition, WEEC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β and IL-6 in HMC-1. The inhibitory effect of WEEC on cytokine expression was nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) dependent. Our results indicate that WEEC inhibits mast cell-mediated allergic inflammatory reactions by suppressing histamine release and proinflammatory cytokine expression, and involvement of calcium, NF-κB and p38 MAPK in these effects.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Hui-Hun Kim et al. (2011). Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-κB. Experimental Biology and Medicine, 236(9), 1070–1077. doi: 10.1258/ebm.2011.011017
Type
Article
ISSN
1535-3702
Source
http://journals.sagepub.com/doi/10.1258/ebm.2011.011017
DOI
10.1258/ebm.2011.011017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35721
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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